Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.40 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18422247 | 1.00 | MEN1 (0.46) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL1451594 | 1.00 | MEN1 (0.46) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL6050397 | 1.00 | MEN1 (0.46) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL677748 | 0.98 | CYP1A2 (0.44) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL677482 | 0.93 | CYP1A2 (0.50) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL6050423 | 0.91 | MEN1 (0.40) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL1404339 | 0.87 | MCHR1 (0.39) | MEN1LMNACHRM2MAPTHTR2B | |
| SCHEMBL8166039 | 0.85 | CYP1A2 (0.45) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL11375442 | 0.83 | CYP1A2 (0.43) | MAPTMCHR1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL15410684 | 0.83 | NR5A1 (0.40) | MEN1NR1I2LMNACHRM2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124552-B1 | TRANS-DISUBSTITUTED BENZODIAZAPORPHYRINS AS SENSITIZERS FOR SOLAR CELLS | UNIV NANTES (FR) | 2018-04-11 | — | — | EP | disclosed |
| WO-2017017118-A1 | TRANS-DISUBSTITUTED BENZODIAZAPORPHYRINS AS SENSITIZERS FOR SOLAR CELLS | UNIVERSITE DE NANTES (FR) | 2017-02-02 | — | — | WO | disclosed |
| EP-3124552-A1 | TRANS-DISUBSTITUTED BENZODIAZAPORPHYRINS AS SENSITIZERS FOR SOLAR CELLS | Université de Nantes (FR) | 2017-02-01 | — | — | EP | disclosed |
| CN-102816130-B | Thiazole compound and use thereof | OTSUKA PHARMA CO LTD | 2015-05-06 | — | — | CN | disclosed |
| US-8450352-B2 | Thiazole compounds and their use for inhibiting phosphodiesterase 4, TNF-α, and IL-4 | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-05-28 | — | — | US | disclosed |
| US-20100094002-A1 | Thiazole Compound and Use Thereof | OTSUKA PHARMACEUTICAL CO., LTD. | 2010-04-15 | — | — | US | disclosed |
| US-7655680-B2 | (E)-3-[2-(3,4-diethoxyphenyl)thiazole-4-yl]-1-(2-methoxyphenyl)propenone; inhibiting the activity of phosphodiesterase 4, the production of tumor necrosis factor alpha, and the production of interleukin 4; atopic dermatitis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2010-02-02 | — | — | US | disclosed |
| US-20080039511-A1 | Thiazole Compound and Use Thereof | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-02-14 | — | — | US | disclosed |
| EP-1748044-A1 | THIAZOLE COMPOUND AND USE THEREOF | Otsuka Pharmaceutical Company, Limited (JP) | 2007-01-31 | — | — | EP | disclosed |
| EP-0510449-B1 | Acid-cleavable compounds, positive-working radiation-sensitive composition containing the same and radiation-sensitive recording material prepared therefrom | CLARIANT GMBH (DE) | 1998-08-05 | — | — | EP | disclosed |
| EP-0510449-A2 | Acid-cleavable compounds, positive-working radiation-sensitive composition containing the same and radiation-sensitive recording material prepared therefrom | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-10-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100094002-A1 | Thiazole Compound and Use Thereof | PDE3B, IL4, PDE4A | MEN1 1975/4885NR1I2 1936/4885LMNA 3792/4885 |
| US-20080039511-A1 | Thiazole Compound and Use Thereof | PDE3B, PDE3A, PDE4A | MEN1 2252/4885NR1I2 2212/4885LMNA 2248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.