Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | CTSC | P53634 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1911244 | 1.00 | SIGMAR1 (0.61) | SIGMAR1MEN1KMT2AUSP30CTSL | |
| SCHEMBL360013 | 0.85 | MAPT (0.56) | SIGMAR1MEN1KMT2APOLBEPHX2 | |
| SCHEMBL1911231 | 0.85 | EPHX2 (0.62) | MEN1KMT2AUSP30CTSLCTSB | |
| SCHEMBL24381758 | 0.84 | MEN1 (0.67) | MEN1KMT2AUSP30CTSLCTSB | |
| SCHEMBL356730 | 0.83 | CTSL (0.65) | KMT2AUSP30CTSLCTSBCTSS | |
| SCHEMBL1908655 | 0.81 | EPHX1 (0.61) | MEN1KMT2AUSP30CTSLCTSB | |
| SCHEMBL12086274 | 0.81 | USP30 (0.50) | MEN1KMT2AUSP30CTSLCTSB | |
| SCHEMBL359016 | 0.81 | EPHX1 (0.64) | MEN1KMT2AUSP30CTSLCTSB | |
| SCHEMBL2752680 | 0.80 | EPHX1 (0.68) | SIGMAR1MEN1KMT2AEPHX2RAB9A | |
| SCHEMBL359836 | 0.80 | CA12 (0.66) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013211-B1 | PURINE DERIVATIVES FOR USE AS ADENOSIN A2A RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2012-03-14 | — | — | EP | disclosed |