Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.68 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.68 |
| ▸ | PIM1 | P11309 | 3/20 | 0.68 |
| ▸ | PRKACA | P17612 | 3/20 | 0.68 |
| ▸ | CLK2 | P49760 | 3/20 | 0.68 |
| ▸ | GSK3B | P49841 | 3/20 | 0.68 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.68 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.68 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.68 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.68 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.68 |
| ▸ | KDR | P35968 | 2/20 | 0.68 |
| ▸ | PRKX | P51817 | 2/20 | 0.68 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.68 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.68 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.68 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.68 |
| ▸ | CDK8 | P49336 | 1/20 | 0.68 |
| ▸ | CDK7 | P50613 | 1/20 | 0.68 |
| ▸ | CDK9 | P50750 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1852018 | 0.92 | CHEK1 (0.61) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL1852190 | 0.91 | CHEK1 (0.71) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL1850053 | 0.90 | CHEK1 (0.68) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL1847547 | 0.88 | CHEK1 (0.75) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL1848026 | 0.87 | CHEK1 (0.71) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL1851372 | 0.87 | CDK9 (0.71) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL1852127 | 0.86 | CDK9 (0.65) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL1851891 | 0.86 | ROCK1 (0.68) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL1850072 | 0.86 | CHEK1 (0.67) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL3601418 | 0.85 | CHEK1 (0.68) | CHEK1MAP4K4PIM1PRKACACLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035919-A1 | COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASES | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | claimed |
| EP-1553074-B1 | FUSED BENZENE DERIVATIVE AND USE | TAKEDA PHARMACEUTICAL (JP) | 2014-06-18 | — | — | EP | disclosed |
| US-20100035919-A1 | COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASES | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | disclosed |
| US-7649001-B2 | Fused benzene derivative and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-01-19 | — | — | US | disclosed |
| US-20090042857-A1 | Novel Pharmaceutical | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-02-12 | — | — | US | disclosed |
| EP-1987827-A1 | NOVEL PHARMACEUTICAL | Takeda Pharmaceutical Company Limited (JP) | 2008-11-05 | — | — | EP | disclosed |
| US-20060106067-A1 | Fused benzene derivative and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-05-18 | — | — | US | disclosed |
| EP-1553074-A1 | FUSED BENZENE DERIVATIVE AND USE | Takeda Pharmaceutical Company Limited (JP) | 2005-07-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106067-A1 | Fused benzene derivative and use | AR, NR5A1, CBR3 | CHEK1 2815/4885MAP4K4 2631/4885PIM1 3907/4885 |
| US-20100035919-A1 | COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASES | ROCK1, ROCK2, RHOA | CHEK1 434/4885MAP4K4 105/4885PIM1 820/4885 |
| US-20090042857-A1 | Novel Pharmaceutical | AR, NR5A1, NR5A2 | CHEK1 3335/4885MAP4K4 1900/4885PIM1 3838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.