SCHEMBL359546

SCHEMBL359546

COc1ccc(Cc2nc3c(ncn3C(CCCc3ccccc3)C(C)=O)c(=O)[nH]2)cc1OC

nearest known ligand 0.51

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PDE2A O00408 11/20 0.51
POLB P06746 1/20 0.40
CCNE2 O96020 1/20 0.40
CDK4 P11802 1/20 0.40
CCND1 P24385 1/20 0.40
CCNE1 P24864 1/20 0.40
CDK2 P24941 1/20 0.40
ALDH1A1 P00352 2/20 0.39
TP53 P04637 1/20 0.39
HPGD P15428 1/20 0.39
MAPK1 P28482 1/20 0.39
RNASEH1 O60930 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.38
EBP Q15125 2/20 0.38
SIGMAR1 Q99720 2/20 0.38
TMEM97 Q5BJF2 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6024368 0.94 PDE2A (0.46) PDE2APOLBCCNE2CDK4CCND1
SCHEMBL6024717 0.94 PDE2A (0.46) PDE2APOLBCCNE2CDK4CCND1
SCHEMBL7442320 0.87 PDE2A (0.52) PDE2ACCNE2CCNE1CDK2ALDH1A1
SCHEMBL6023455 0.86 PDE2A (0.43) PDE2ACCNE2CDK4CCND1CCNE1
SCHEMBL6023491 0.86 PDE2A (0.44) PDE2ARNASEH1
SCHEMBL6024017 0.84 PDE2A (0.41) PDE2APOLBALDH1A1TP53RNASEH1
SCHEMBL6992393 0.82 PDE2A (0.55) PDE2APOLBCCNE2CDK4CCND1
SCHEMBL6023204 0.82 PDE2A (0.51) PDE2ARNASEH1
SCHEMBL6023837 0.82 PDE2A (0.51) PDE2ARNASEH1
SCHEMBL6024621 0.81 PDE2A (0.36) PDE2APOLBALDH1A1MAPK1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 208 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024059335-A1 METHODS OF TREATING AGE-RELATED AND INHERITED RETINAL DYSFUNCTIONS UNIVERSITY OF CALIFORNIA - IRVINE (US) 2024-03-21 WO claimed
WO-2024035435-A1 DRUG-COATED MEDICAL DEVICES AND METHODS OF MAKING BARD PERIPHERAL VASCULAR, INC. (US) 2024-02-15 WO claimed
WO-2023012244-A1 COMBINATION THERAPY JAZ Innovation Limited (GB) 2023-02-09 WO claimed
US-20220218630-A1 METHODS AND FORMULATIONS FOR TREATING VISION DISORDERS JENIVISION INC. 2022-07-14 US claimed
CN-113993511-A Methods and formulations for treating visual disorders 杰尼视界公司 2022-01-28 CN claimed
US-20210393639-A1 VASOACTIVE TOPICAL COMPOUND TO AFFECT TISSUE BLOOD FLOW, REDUCE TISSUE NECROSIS AND PROMOTE HEALING SOUTH DAKOTA BOARD OF REGENTS 2021-12-23 US claimed
US-20210330736-A1 USE OF A PDE11 OR PDE2 INHIBITOR FOR THE TREATMENT OF PARKINSON'S DISEASE UNIVERSITEIT VAN AMSTERDAM (NL) 2021-10-28 US claimed
EP-3846788-A1 USE OF A PDE11 OR PDE2 INHIBITOR FOR THE TREATMENT OF PARKINSON'S DISEASE Universiteit van Amsterdam (NL) 2021-07-14 EP claimed
CN-112996492-A Use of PDE11 or PDE2 inhibitors for the treatment of Parkinson's disease 阿姆斯特丹大学 2021-06-18 CN claimed
WO-2020185674-A1 A VASOACTIVE TOPICAL COMPOUND TO AFFECT TISSUE BLOOD FLOW, REDUCE TISSUE NECROSIS AND PROMOTE HEALING SOUTH DAKOTA BOARD OF REGENTS (US) 2020-09-17 WO claimed
EP-3013352-B1 MECHANISM AND DRUG TARGETS FOR REDUCING CELL EDEMA (NEUROPROTECTION) AND CYTOPLASMIC EXCITABILITY IN ASTROCYTES IN NORMAL AND PATHOLOGICAL STATES CELICA BIOMEDICAL (SI) 2018-09-05 EP claimed
US-20160139112-A1 MECHANISM AND DRUG TARGETS FOR REDUCING CELL EDEMA (NEUROPROTECTION) AND CYTOPLASMIC EXCITABILITY IN ASTROCYTES IN NORMAL AND PATHOLOGICAL STATES CELICA BIOMEDICAL (SI) 2016-05-19 US claimed
EP-3013352-A1 MECHANISM AND DRUG TARGETS FOR REDUCING CELL EDEMA (NEUROPROTECTION) AND CYTOPLASMIC EXCITABILITY IN ASTROCYTES IN NORMAL AND PATHOLOGICAL STATES Celica BIOMEDICAL (SI) 2016-05-04 EP claimed
WO-2014206948-A1 MECHANISM AND DRUG TARGETS FOR REDUCING CELL EDEMA (NEUROPROTECTION) AND CYTOPLASMIC EXCITABILITY IN ASTROCYTES IN NORMAL AND PATHOLOGICAL STATES CELICA D.O.O. (SI) 2014-12-31 WO claimed
EP-2818177-A1 Mechanism and drug targets for reducing cell edema (neuroprotection) and cytoplasmic excitability in astrocytes in normal and pathological states Celica, D.O.O. (SI) 2014-12-31 EP claimed
US-20060229242-A1 Composition comprising a pulmonary surfactant and a pde2 inhibitor ALTANA PHAZMA AG (DE) 2006-10-12 US claimed
EP-1660132-A1 COMPOSITION COMPRISING A PULMONARY SURFACTANT AND A PDE2 INHIBITOR ALTANA Pharma AG (DE) 2006-05-31 EP claimed
WO-2005021037-A1 COMPOSITION COMPRISING A PULMONARY SURFACTANT AND A PDE2 INHIBITOR ALTANA PHARMA AG (DE) 2005-03-10 WO claimed
EP-3870300-B1 IMIDAZO[1,5-A]PYRAZINE COMPOUNDS AS PDE2 INHIBITORS INTRA CELLULAR THERAPIES INC (US) 2024-07-10 EP disclosed
EP-1097707-A1 Treatment of female sexual dysfunction Pfizer Limited (GB) 2001-05-09 EP disclosed