Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 5/20 | 0.43 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 8/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.33 |
| ▸ | CDK2 | P24941 | 8/20 | 0.33 |
| ▸ | CDK4 | P11802 | 6/20 | 0.33 |
| ▸ | CCND1 | P24385 | 6/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.33 |
| ▸ | CDK1 | P06493 | 4/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE9A | O76083 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
| ▸ | CCNK | O75909 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6024717 | 0.91 | PDE2A (0.46) | PDE2ARNASEH1CCNE2CCNE1CDK2 | |
| SCHEMBL6024368 | 0.91 | PDE2A (0.46) | PDE2ARNASEH1CCNE2CCNE1CDK2 | |
| SCHEMBL6023491 | 0.90 | PDE2A (0.44) | PDE2ARNASEH1PDE9APDE1APDE1B | |
| SCHEMBL6023263 | 0.88 | PDE2A (0.44) | PDE2ARNASEH1 | |
| SCHEMBL6024017 | 0.87 | PDE2A (0.41) | PDE2ARNASEH1PDE9APDE1APDE1B | |
| SCHEMBL359546 | 0.86 | PDE2A (0.51) | PDE2ARNASEH1CCNE2CCNE1CDK2 | |
| SCHEMBL6024990 | 0.85 | PDE2A (0.38) | PDE2APDE5APDE4APDE4BPDE4C | |
| SCHEMBL7442320 | 0.83 | PDE2A (0.52) | PDE2ARNASEH1CCNE2CCNE1CDK2 | |
| SCHEMBL6023286 | 0.82 | PDE2A (0.37) | PDE2ARNASEH1PDE5A | |
| SCHEMBL6023285 | 0.82 | PDE2A (0.38) | PDE2APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060106037-A1 | Purin-6-one-derivatives | ALTANA PHARMA AG (DE) | 2006-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106037-A1 | Purin-6-one-derivatives | PDE4B, PDE4A, PDE2A | PDE2A 3/4885RNASEH1 450/4885CCNE2 3084/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.