Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 7/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3603572 | 0.91 | MAPT (0.42) | GRIN2BSMN1; SMN2RAB9AP2RX7BCHE | |
| SCHEMBL3603868 | 0.86 | ADORA2A (0.41) | GRIN2BPOLBSMN1; SMN2RAB9AP2RX7 | |
| SCHEMBL3608260 | 0.85 | GRIN2B (0.42) | GRIN2BPOLBSMN1; SMN2RAB9AMEN1 | |
| SCHEMBL3595659 | 0.83 | MEN1 (0.41) | GRIN2BPOLBMEN1KMT2AHCRTR1 | |
| SCHEMBL3598310 | 0.82 | NPC1 (0.46) | POLBSMN1; SMN2P2RX7BCHEHTR6 | |
| SCHEMBL3600291 | 0.81 | GRIN2B (0.55) | GRIN2BPOLBSMN1; SMN2RAB9ANPY5R | |
| SCHEMBL3588047 | 0.81 | GRIN2B (0.52) | GRIN2BPOLBSMN1; SMN2RAB9ANPY5R | |
| SCHEMBL3606204 | 0.80 | GRIN2B (0.41) | GRIN2BPOLBSMN1; SMN2RAB9AMEN1 | |
| SCHEMBL3600784 | 0.79 | GRIN2B (0.48) | GRIN2BPOLBNPY5R | |
| SCHEMBL3595022 | 0.78 | HSD17B10 (0.55) | SMN1; SMN2KMT2ANPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7807704-B2 | Bicyclic, nitrogen-containing compounds modulating CXCR4 and/or CCXCKR2 | CHEMOCENTRYX, INC. (US) | 2010-10-05 | — | — | US | disclosed |
| US-20070275965-A1 | CXCR4 modulators | CHEMOCENTRYX, INC. (US) | 2007-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275965-A1 | CXCR4 modulators | CXCL12, CXCR4, CXCR1 | GRIN2B 2950/4885POLB 4479/4885SMN1; SMN2 4228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.