Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 11/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.43 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 6/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3595932 | 0.90 | DPP4 (0.49) | DPP4CNR1CXCR2DPP8DPP9 | |
| SCHEMBL3600802 | 0.90 | DPP4 (0.44) | DPP4CNR1CXCR2DPP8NSD2 | |
| SCHEMBL3600269 | 0.86 | DPP4 (0.41) | DPP4CNR1CXCR2DPP8CYP3A4 | |
| SCHEMBL3602753 | 0.86 | DPP4 (0.41) | DPP4CNR1CXCR2CRHR1DPP8 | |
| SCHEMBL3606760 | 0.86 | DPP4 (0.44) | DPP4CNR1DPP8DPP9CYP3A4 | |
| SCHEMBL3604955 | 0.85 | DPP4 (0.48) | DPP4CNR1CXCR2DPP8DPP9 | |
| SCHEMBL3586864 | 0.82 | DPP4 (0.45) | DPP4CNR1CXCR2DPP8CYP3A4 | |
| SCHEMBL3601749 | 0.82 | DPP4 (0.47) | DPP4CRHR1DPP8CYP3A4LMNA | |
| SCHEMBL3096850 | 0.81 | DPP4 (0.44) | DPP4DPP8CYP3A4NSD2 | |
| SCHEMBL3091767 | 0.81 | DPP4 (0.50) | DPP4CNR1CRHR1DPP8NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728146-B2 | Enzyme inhibitors | PROBIODRUG AG (DE) | 2010-06-01 | — | — | US | claimed |