Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 11/20 | 0.49 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 6/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | QPCT | Q16769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3595753 | 0.90 | DPP4 (0.47) | DPP4CXCR2CNR1DPP8DPP9 | |
| SCHEMBL3091375 | 0.89 | DPP4 (0.47) | DPP4CXCR2CNR1DPP8CYP3A4 | |
| SCHEMBL3091438 | 0.89 | CXCR2 (0.51) | DPP4CXCR2DPP8DPP9MAPT | |
| SCHEMBL3605962 | 0.88 | DPP4 (0.41) | DPP4DPP8MEN1KMT2AQPCT | |
| SCHEMBL3091436 | 0.87 | DPP4 (0.46) | DPP4CNR1DPP8DPP9CYP3A4 | |
| SCHEMBL3595101 | 0.86 | DPP4 (0.43) | DPP4CXCR2DPP8DPP9CYP3A4 | |
| SCHEMBL3596138 | 0.86 | DPP4 (0.40) | DPP4DPP8 | |
| SCHEMBL3102277 | 0.85 | DPP4 (0.44) | DPP4DPP8TP53LMNAMAPK1 | |
| SCHEMBL3096840 | 0.85 | DPP4 (0.46) | DPP4CNR1DPP8DPP9CYP3A4 | |
| SCHEMBL3595741 | 0.85 | DPP4 (0.44) | DPP4CXCR2CNR1DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728146-B2 | Enzyme inhibitors | PROBIODRUG AG (DE) | 2010-06-01 | — | — | US | claimed |