Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 18/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.41 |
| ▸ | NQO2 | P16083 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | WNT1 | P04628 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14916384 | 0.79 | MET (0.47) | METPDE3ANQO2PDE3BPIP4K2C | |
| SCHEMBL358734 | 0.78 | MET (0.46) | METPDE10A | |
| SCHEMBL359518 | 0.77 | MET (0.52) | METPDE3ANQO2PDE3BPIP4K2C | |
| SCHEMBL14915679 | 0.77 | MET (0.52) | METPDE3ANQO2PDE3BPIP4K2C | |
| SCHEMBL2263079 | 0.76 | WNT1 (0.45) | METPDE3ADYRK1AWNT1PDE10A | |
| SCHEMBL162668 | 0.75 | MET (0.43) | METPDE3ANQO2PDE3BPIP4K2C | |
| SCHEMBL2223043 | 0.74 | MET (0.52) | METPDE10A | |
| SCHEMBL164181 | 0.73 | MET (0.53) | MET | |
| SCHEMBL2269727 | 0.73 | MET (0.52) | METPDE3ANQO2PDE3BPIP4K2C | |
| SCHEMBL367896 | 0.73 | MET (0.44) | METPDE3ANQO2PDE3BPIP4K2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593107-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-22 | — | — | EP | claimed |
| WO-2012009194-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-19 | — | — | WO | claimed |
| EP-2593107-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012009194-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-19 | — | — | WO | disclosed |