Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.43 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 3/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.41 |
| ▸ | CDK2AP1 | O14519 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3596479 | 1.00 | HDAC3 (0.46) | HDAC3HDAC1PARP1MAPK1OPRK1 | |
| SCHEMBL3607376 | 0.94 | HDAC3 (0.47) | HDAC3HDAC1PARP1MLLT1TOP2A | |
| SCHEMBL3607381 | 0.94 | HDAC3 (0.47) | HDAC3HDAC1PARP1MLLT1TOP2A | |
| SCHEMBL3612481 | 0.94 | HDAC3 (0.47) | HDAC3HDAC1PARP1MLLT1TOP2A | |
| Trifluoroacetic Acid SCHEMBL3615445 | 0.89 | HDAC3 (0.44) | HDAC3HDAC1PARP1MLLT1TOP2A | |
| SCHEMBL3597200 | 0.83 | CDK2 (0.50) | PARP1MLLT1CHRNA1CHRNB2CHRNB4 | |
| SCHEMBL3597204 | 0.83 | CDK2 (0.50) | PARP1MLLT1CHRNA1CHRNB2CHRNB4 | |
| SCHEMBL3614229 | 0.81 | PARP1 (0.49) | PARP1MAPK1OPRK1CHRNA1CHRNB2 | |
| SCHEMBL3614233 | 0.81 | PARP1 (0.49) | PARP1MAPK1OPRK1CHRNA1CHRNB2 | |
| SCHEMBL3600224 | 0.81 | PARP1 (0.49) | PARP1MAPK1OPRK1CHRNA1CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | claimed |
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | IDO2, IDO1, INMT | HDAC3 60/4885HDAC1 70/4885PARP1 156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.