Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | GHSR | Q92847 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.45 |
| ▸ | CDK2AP1 | O14519 | 2/20 | 0.45 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.43 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3600227 | 1.00 | PARP1 (0.49) | PARP1MAPK1OPRK1CHRNA1CHRNB2 | |
| SCHEMBL3605671 | 0.93 | SMYD3 (0.50) | PARP1SMYD3RAB9AKDM1A | |
| SCHEMBL3605675 | 0.93 | SMYD3 (0.50) | PARP1SMYD3RAB9AKDM1A | |
| SCHEMBL3611578 | 0.93 | SMYD3 (0.50) | PARP1SMYD3RAB9AKDM1A | |
| SCHEMBL17209756 | 0.87 | RAB9A (0.54) | SMYD3RAB9APLA2G7 | |
| SCHEMBL17209751 | 0.87 | RAB9A (0.54) | SMYD3RAB9APLA2G7 | |
| SCHEMBL3609263 | 0.86 | RAB9A (0.52) | PARP1MAPK1OPRK1CHRNA1CHRNB2 | |
| SCHEMBL3609261 | 0.86 | RAB9A (0.52) | PARP1MAPK1OPRK1CHRNA1CHRNB2 | |
| SCHEMBL3614229 | 0.86 | PARP1 (0.49) | PARP1MAPK1OPRK1CHRNA1CHRNB2 | |
| SCHEMBL3597204 | 0.86 | CDK2 (0.50) | PARP1CHRNA1CHRNB2CHRNB4CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | claimed |
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | IDO2, IDO1, INMT | PARP1 156/4885MAPK1 4292/4885OPRK1 609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.