Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 12/20 | 0.45 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3596963 | 0.83 | DPP4 (0.58) | DPP4DPP8CYP3A4 | |
| SCHEMBL3603728 | 0.83 | DPP4 (0.45) | DPP4DPP8CYP3A4TP53CYP1A2 | |
| SCHEMBL3096567 | 0.82 | DPP4 (0.46) | DPP4DPP8CYP3A4 | |
| SCHEMBL3598301 | 0.82 | DPP4 (0.48) | DPP4DPP8CYP3A4CYP2C19 | |
| SCHEMBL3600930 | 0.81 | DPP4 (0.46) | DPP4DPP8CYP3A4CRHR1 | |
| SCHEMBL3091767 | 0.81 | DPP4 (0.50) | DPP4DPP8CRHR1 | |
| SCHEMBL4660649 | 0.81 | DPP4 (0.48) | DPP4DPP8CYP3A4 | |
| SCHEMBL3600399 | 0.80 | DPP4 (0.42) | DPP4DPP8CYP3A4CRHR1 | |
| SCHEMBL3091375 | 0.80 | DPP4 (0.47) | DPP4DPP8CYP3A4TP53 | |
| SCHEMBL3603864 | 0.79 | DPP4 (0.42) | DPP4DPP8CYP3A4TP53CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728146-B2 | Enzyme inhibitors | PROBIODRUG AG (DE) | 2010-06-01 | — | — | US | claimed |