⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5834889 | 0.68 | — | — | |
| SCHEMBL6669909 | 0.65 | — | — | |
| SCHEMBL18231941 | 0.61 | ALDH1A1 (0.34) | — | |
| SCHEMBL12158688 | 0.60 | CES2 (0.38) | — | |
| SCHEMBL17367607 | 0.60 | ALDH1A1 (0.46) | — | |
| SCHEMBL11160009 | 0.59 | TP53 (0.35) | — | |
| Propionic Acid SCHEMBL28425835 | 0.58 | FFAR3 (0.36) | — | |
| SCHEMBL24709169 | 0.57 | DPP4 (0.33) | — | |
| SCHEMBL10664271 | 0.56 | — | — | |
| SCHEMBL327566 | 0.55 | CES2 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2407536-B1 | ADP-ribosyl transferase fusion variant proteins | BIOAXONE BIOSCIENCES INC (US) | 2013-10-30 | — | — | EP | disclosed |
| EP-2407536-A9 | ADP-ribosyl transferase fusion variant proteins | Bioaxone Biosciences Inc. (US) | 2013-03-13 | — | — | EP | disclosed |
| EP-2407536-A1 | ADP-ribosyl transferase fusion variant proteins | Bioaxone Therapeutique Inc. (CA) | 2012-01-18 | — | — | EP | disclosed |
| US-7910554-B2 | Biodrugs comprising polypeptides and carriers comprising bioadhesives such as fibrin, for treatment of vision defects; chimeric C3-like Rho antagonists and their use for promoting repair and neuron survival in injured mammalian central and peripheral nervous system and for treating cancer | BIOAXONE THERAPEUTIQUE INC. (CA) | 2011-03-22 | — | — | US | disclosed |
| US-7795218-B2 | ADP-ribosyl transferase fusion variant proteins | BIOAXONE THERAPEUTIQUE INC. (CA) | 2010-09-14 | — | — | US | disclosed |
| EP-1377319-B1 | FUSION PROTEINS | BIOAXONE THERAPEUTIQUE INC (CA) | 2010-09-08 | — | — | EP | disclosed |
| US-20090053190-A1 | Treatment of macular degeneration with ADP-ribosyl transferase fusion protein therapeutic compositions | BIOAXONE BIOSCIENCES INC. | 2009-02-26 | — | — | US | disclosed |
| US-20080269120-A1 | ADP-ribosyl transferase fusion variant proteins | BIOAXONE THERAPEUTIQUE INC. (CA) | 2008-10-30 | — | — | US | disclosed |
| US-7442686-B2 | Treatment of macular degeneration with ADP-ribosyl transferase fusion protein therapeutic compositions | BIOAXONE THERAPEUTIQUE INC. (CA) | 2008-10-28 | — | — | US | disclosed |
| US-20070270340-A1 | ADP-ribosyl transferase fusion variant proteins | BIOAXONE BIOSCIENCES INC. | 2007-11-22 | — | — | US | disclosed |
| US-7141428-B2 | Methods for making and delivering rho-antagonist tissue adhesive formulations to the injured mammalian central and peripheral nervous systems and uses thereof | BIOAXONE BIOSCIENCES INC. | 2006-11-28 | — | — | US | disclosed |
| US-20050059595-A1 | Treatment of macular degeneration with ADP-ribosyl transferase fusion protein therapeutic compositions | BIOAXONE BIOSCIENCES INC. | 2005-03-17 | — | — | US | disclosed |
| US-6855688-B2 | ADP-ribosyl transferase fusion proteins, pharmaceutical compositions, and methods of use | Bioaxone Thérapeutique Inc. (CA) | 2005-02-15 | — | — | US | disclosed |
| US-20030103957-A1 | Fusion proteins | BIOAXONE BIOSCIENCES INC. | 2003-06-05 | — | — | US | disclosed |
| EP-0370498-A2 | Trans-4-amino(alkyl)-1-pyridylcarbamoylcyclohexane compounds and pharmaceutical use thereof | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1990-05-30 | — | — | EP | disclosed |