Sugi Predict

Sugi Predict / Compounds / SCHEMBL359793

SCHEMBL359793

SCHEMBL359793

Nc1cccc(N)c1N1CCCCC1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KEAP1 Q14145 1/20 0.59
▸ ALDH1A1 P00352 7/20 0.45
▸ GAA P10253 6/20 0.45
▸ HTT P42858 4/20 0.45
▸ MAPT P10636 4/20 0.45
▸ MEN1 O00255 3/20 0.45
▸ KMT2A Q03164 3/20 0.45
▸ L3MBTL1 Q9Y468 3/20 0.45
▸ ALOX15 P16050 2/20 0.45
▸ KDM4E B2RXH2 2/20 0.45
▸ POLB P06746 2/20 0.45
▸ THRB P10828 2/20 0.45
▸ RECQL P46063 2/20 0.45
▸ NPC1 O15118 1/20 0.45
▸ USP2 O75604 1/20 0.45
▸ TP53 P04637 1/20 0.45
▸ RAB9A P51151 1/20 0.45
▸ NPSR1 Q6W5P4 1/20 0.45
▸ HSD17B10 Q99714 1/20 0.45
▸ S100B P04271 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23044089 0.86 KEAP1 (0.50) KEAP1ALDH1A1GAAHTTMAPT
SCHEMBL29978841 0.86 KEAP1 (0.50) KEAP1ALDH1A1GAAHTTMAPT
SCHEMBL29931924 0.86 KEAP1 (0.50) KEAP1ALDH1A1HTTL3MBTL1KDM4E
SCHEMBL5092052 0.86 KEAP1 (0.50) KEAP1ALDH1A1HTTL3MBTL1KDM4E
SCHEMBL5092234 0.86 ALDH1A1 (0.51) KEAP1ALDH1A1GAAHTTMAPT
Hydrochloric Acid SCHEMBL29978819 0.84 KEAP1 (0.48) KEAP1ALDH1A1GAAHTTMAPT
Hydrochloric Acid SCHEMBL23043631 0.84 KEAP1 (0.48) KEAP1ALDH1A1GAAHTTMAPT
SCHEMBL22662669 0.83 KEAP1 (0.47) KEAP1ALDH1A1GAAHTTMAPT
SCHEMBL30667343 0.83 KEAP1 (0.47) KEAP1ALDH1A1GAAHTTMAPT
SCHEMBL30667342 0.83 ALDH1A1 (0.49) KEAP1ALDH1A1GAAHTTMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110003219-A Pyrazolo [1,5A] pyrimidine and thieno [3,2B] pyrimidine derivatives as IRAK4 regulator 弗·哈夫曼-拉罗切有限公司 2019-07-12 — — CN claimed
CN-107177030-B A kind of halogen-free thermosetting resin composite and prepreg and laminate for printed circuits using it 广东生益科技股份有限公司 2019-06-14 — — CN claimed
CN-107151308-B A kind of halogen-free thermosetting resin composite and prepreg, laminate for printed circuits using it 广东生益科技股份有限公司 2019-06-14 — — CN claimed
CN-107227001-B A kind of halogen-free thermosetting resin composite and prepreg, laminate and printed circuit board containing it 广东生益科技股份有限公司 2019-06-14 — — CN claimed
CN-109337289-A Compositions of thermosetting resin and prepreg, laminate and high-frequency circuit board containing it 广东生益科技股份有限公司 2019-02-15 — — CN claimed
CN-108117723-A A kind of compositions of thermosetting resin and use its prepreg and laminate for printed circuits 广东生益科技股份有限公司 2018-06-05 — — CN claimed
CN-105801814-B A kind of halogen-free thermosetting resin composite and use its prepreg and laminate for printed circuits 广东生益科技股份有限公司 2018-05-04 — — CN claimed
CN-105802128-B A kind of halogen-free thermosetting resin composite and use its prepreg and laminate for printed circuits 广东生益科技股份有限公司 2018-05-04 — — CN claimed
CN-105802127-B A kind of halogen-free thermosetting resin composite and use its prepreg and laminate for printed circuits 广东生益科技股份有限公司 2018-05-04 — — CN claimed
CN-105331053-B A kind of halogen-free resin composition and use its prepreg and laminate for printed circuits 广东生益科技股份有限公司 2017-12-05 — — CN claimed
CN-107227001-A A kind of halogen-free thermosetting resin composite and prepreg, laminate and printed circuit board containing it 广东生益科技股份有限公司 2017-10-03 — — CN claimed
CN-107177030-A A kind of halogen-free thermosetting resin composite and use its prepreg and laminate for printed circuits 广东生益科技股份有限公司 2017-09-19 — — CN claimed
CN-107151308-A A kind of halogen-free thermosetting resin composite and use its prepreg, laminate for printed circuits 广东生益科技股份有限公司 2017-09-12 — — CN claimed
CN-110003219-A Pyrazolo [1,5A] pyrimidine and thieno [3,2B] pyrimidine derivatives as IRAK4 regulator 弗·哈夫曼-拉罗切有限公司 2019-07-12 — — CN disclosed
CN-107151308-B A kind of halogen-free thermosetting resin composite and prepreg, laminate for printed circuits using it 广东生益科技股份有限公司 2019-06-14 — — CN disclosed
CN-105367577-B Pyrazolo [1,5A] pyrimidine and thieno [3,2B] pyrimidine derivatives as IRAK4 regulator 弗·哈夫曼-拉罗切有限公司 2019-04-23 — — CN disclosed
US-20120015962-A1 PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS ARORA NIDHI (US) 2012-01-19 — — US disclosed
US-20120015962-A1 PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS ARORA NIDHI (US) 2012-01-19 — — US disclosed
US-RE30199-E Oxidation hair dyes based upon tetraaminopyrimidine developers HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) 1980-01-29 — — US disclosed
US-4003699-A Oxidation hair dyes based upon tetraaminopyrimidine developers HENKEL & CIE G.M.B.H. (DT) 1977-01-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120015962-A1 PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS IRAK4, IRAK1, IRAK2 KEAP1 1611/4885ALDH1A1 2519/4885GAA 4543/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.