Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 11/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.40 |
| ▸ | MDM4 | O15151 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3598301 | 0.88 | DPP4 (0.48) | DPP4CYP3A4DPP8DPP9CNR1 | |
| SCHEMBL3603728 | 0.85 | DPP4 (0.45) | DPP4CYP3A4DPP8MDM4TP53 | |
| SCHEMBL3604955 | 0.84 | DPP4 (0.48) | DPP4CYP3A4DPP8DPP9CNR1 | |
| SCHEMBL3600919 | 0.83 | MDM4 (0.42) | DPP4CYP3A4DPP8MDM4TP53 | |
| SCHEMBL3079559 | 0.82 | DPP4 (0.51) | DPP4CYP3A4DPP8MDM4TP53 | |
| SCHEMBL3585733 | 0.82 | DPP4 (0.46) | DPP4CYP3A4DPP8DPP9CNR1 | |
| SCHEMBL3601689 | 0.82 | DPP4 (0.46) | DPP4CYP3A4DPP8 | |
| SCHEMBL3603961 | 0.81 | DPP4 (0.46) | DPP4CYP3A4DPP8DPP9CNR1 | |
| SCHEMBL3590139 | 0.81 | DPP4 (0.46) | DPP4CYP3A4DPP8DPP9CNR1 | |
| SCHEMBL3091767 | 0.81 | DPP4 (0.50) | DPP4DPP8HSD11B1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728146-B2 | Enzyme inhibitors | PROBIODRUG AG (DE) | 2010-06-01 | — | — | US | claimed |