Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 4/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3600935 | 0.87 | TP53 (0.45) | MDM4TP53MDM2DPP4HSD11B1 | |
| SCHEMBL3594733 | 0.85 | CXCR2 (0.44) | MDM4TP53MDM2DPP4HSD11B1 | |
| SCHEMBL3593028 | 0.84 | ALDH1A1 (0.44) | MDM4TP53MDM2DPP4HSD11B1 | |
| SCHEMBL3597273 | 0.83 | CXCR2 (0.40) | MDM4TP53MDM2DPP4HSD11B1 | |
| SCHEMBL3598381 | 0.83 | DPP4 (0.49) | MDM4TP53MDM2DPP4HSD11B1 | |
| SCHEMBL3599359 | 0.83 | CXCR2 (0.40) | MDM4TP53MDM2DPP4HSD11B1 | |
| SCHEMBL3599723 | 0.82 | CNR1 (0.42) | MDM4TP53MDM2DPP4HSD11B1 | |
| SCHEMBL3601200 | 0.81 | TP53 (0.38) | MDM4TP53MDM2DPP4HSD11B1 | |
| SCHEMBL3607967 | 0.81 | DPP4 (0.41) | DPP4HSD11B1DPP8CNR1 | |
| SCHEMBL3595829 | 0.81 | CYP3A4 (0.44) | MDM4TP53MDM2DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728146-B2 | Enzyme inhibitors | PROBIODRUG AG (DE) | 2010-06-01 | — | — | US | claimed |