Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL204974 | 1.00 | HSD17B10 (0.56) | HSD17B10SMN1; SMN2ALDH1A1NPC1LMNA | |
| SCHEMBL2707102 | 1.00 | HSD17B10 (0.56) | HSD17B10SMN1; SMN2ALDH1A1NPC1LMNA | |
| SCHEMBL30987668 | 0.95 | HSD17B10 (0.51) | HSD17B10SMN1; SMN2ALDH1A1NPC1LMNA | |
| SCHEMBL10031609 | 0.86 | HSD17B10 (0.57) | HSD17B10SMN1; SMN2ALDH1A1NPC1LMNA | |
| SCHEMBL13871981 | 0.86 | HSD17B10 (0.57) | HSD17B10SMN1; SMN2ALDH1A1NPC1LMNA | |
| SCHEMBL903389 | 0.86 | HSD17B10 (0.57) | HSD17B10SMN1; SMN2ALDH1A1NPC1LMNA | |
| SCHEMBL8389716 | 0.85 | HSD17B10 (0.56) | HSD17B10SMN1; SMN2ALDH1A1NPC1LMNA | |
| SCHEMBL6948605 | 0.85 | HSD17B10 (0.56) | HSD17B10SMN1; SMN2ALDH1A1NPC1LMNA | |
| SCHEMBL6941435 | 0.85 | HSD17B10 (0.56) | HSD17B10SMN1; SMN2ALDH1A1NPC1LMNA | |
| SCHEMBL2259135 | 0.85 | HSD17B10 (0.56) | HSD17B10SMN1; SMN2ALDH1A1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8841278-B2 | Antiviral compounds | GILEAD PHARMASSET LLC (US) | 2014-09-23 | — | — | US | disclosed |
| US-20140039021-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2014-02-06 | — | — | US | disclosed |
| US-20100298314-A1 | NOVEL JNK INHIBITORS | SCHERING CORPORATION | 2010-11-25 | — | — | US | disclosed |
| EP-2134713-A2 | NOVEL JNK INHIBITORS | SCHERING CORPORATION (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008082490-A2 | NOVEL JNK INHIBITORS | SCHERING CORPORATION (US) | 2008-07-10 | — | — | WO | disclosed |
| WO-2004041795-A1 | NOVEL INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | GUILFORD PHARMACEUTICALS INC. (US) | 2004-05-21 | — | — | WO | disclosed |
| US-4643991-A | TREATMENT OF EMPHYSEMA | THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 1987-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298314-A1 | NOVEL JNK INHIBITORS | MAPK1, MAPKAPK2, MAP4K2 | HSD17B10 3024/4885SMN1; SMN2 2617/4885ALDH1A1 1430/4885 |
| US-20140039021-A1 | ANTIVIRAL COMPOUNDS | MAVS, EIF2AK2, ZC3HAV1 | HSD17B10 3314/4885SMN1; SMN2 1564/4885ALDH1A1 3957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.