Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Di(Hydroxyethyl)Ether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.33 |
| ▸ | NOS3 known ✓ | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 known ✓ | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 known ✓ | P35228 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 4/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Di(Hydroxyethyl)Ether SCHEMBL9325783 | 1.00 | TSHR (0.62) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Di(Hydroxyethyl)Ether SCHEMBL27615302 | 1.00 | TSHR (0.62) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Di(Hydroxyethyl)Ether SCHEMBL4528960 | 1.00 | TSHR (0.62) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Di(Hydroxyethyl)Ether SCHEMBL8642258 | 1.00 | TSHR (0.62) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Di(Hydroxyethyl)Ether SCHEMBL28435040 | 1.00 | TSHR (0.62) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Di(Hydroxyethyl)Ether SCHEMBL271069 | 1.00 | TSHR (0.62) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Triethylene Glycol SCHEMBL7049732 | 0.97 | MEN1 (0.65) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Pentaethylene Glycol SCHEMBL9614725 | 0.97 | MEN1 (0.65) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Triethylene Glycol SCHEMBL994880 | 0.97 | MEN1 (0.65) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Acetic Acid SCHEMBL21878891 | 0.97 | MEN1 (0.65) | TSHRMAPK1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5961 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122080897-A | Blocking remover, and preparation method and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-119805862-A | Colored photosensitive resin composition, color filter, developing device and preparation method | 阜阳欣奕华新材料科技股份有限公司 | 2025-04-11 | — | — | CN | claimed |
| CN-119489163-A | Method for preparing metal casting mold based on steel grit 3D printing | 沈阳艾科思邦工业材料有限公司 | 2025-02-21 | — | — | CN | claimed |
| CN-119035053-B | Ceramic aluminum-based silicon carbide layered composite material and preparation method thereof | 广州众山功能材料有限公司 | 2025-02-21 | — | — | CN | claimed |
| CN-119410199-A | Anti-counterfeiting digital invisible printing ink and application thereof | 赛维精密科技(广东)有限公司 | 2025-02-11 | — | — | CN | claimed |
| CN-119035053-A | Ceramic aluminum-based silicon carbide layered composite material and preparation method thereof | 广州众山功能材料有限公司 | 2024-11-29 | — | — | CN | claimed |
| US-20240270952-A1 | PHOTOSENSITIVE RESIN COMPOSITION, METHOD FOR PRODUCING CURED PRODUCT OF FLUORORESIN, FLUORORESIN, FLUORORESIN FILM, BANK AND DISPLAY ELEMENT | CENTRAL GLASS CO LTD (JP) | 2024-08-15 | — | — | US | claimed |
| WO-2024152687-A1 | CONDUCTIVE INK, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海宇叠智能科技有限公司 | 2024-07-25 | — | — | WO | claimed |
| CN-118059521-A | Preparation method and system of flame-retardant unsaturated polyester resin | 西安新三力复合材料科技有限公司 | 2024-05-24 | — | — | CN | claimed |
| US-11939459-B2 | Photosensitive resin composition, method for producing cured product of fluororesin, fluororesin, fluororesin film, bank and display element | CENTRAL GLASS COMPANY, LIMITED (JP) | 2024-03-26 | — | — | US | claimed |
| US-4647309-A | Waterborne firm coating for temporary protection of parts, providing controlled lubrication during assembly | ASHLAND OIL, INC. (US) | 1987-03-03 | — | — | US | claimed |
| US-4479981-A | CORROSION RESISTANCE | ASHLAND OIL, INC. (US) | 1984-10-30 | — | — | US | claimed |
| US-4460718-A | EPOXY-MODIFIED 1-O-TOLYLBIGUANIDE | HITACHI, LTD. (JP) | 1984-07-17 | — | — | US | claimed |
| US-4444802-A | WAXES, ESTERS, ALCOHOLIC COUPLING SOLVENT | ASHLAND OIL, INC. (US) | 1984-04-24 | — | — | US | claimed |
| US-4444803-A | Water-borne soft coating compositions and processes therefor | ASHLAND OIL, INC. (US) | 1984-04-24 | — | — | US | claimed |
| EP-0093324-A1 | Water-borne firm coating compositions and processes therefor | ASHLAND OIL, INC. (US) | 1983-11-09 | — | — | EP | claimed |
| EP-0093323-A1 | Water-borne hard coating compositions and processes therefor | ASHLAND OIL, INC. (US) | 1983-11-09 | — | — | EP | claimed |
| EP-0093388-A2 | Water-borne soft coating compositions and processes therefor | ASHLAND OIL, INC. (US) | 1983-11-09 | — | — | EP | claimed |
| US-4395463-A | Article comprising silicone resin coated, methacrylate-primed substrate | GENERAL ELECTRIC COMPANY (US) | 1983-07-26 | — | — | US | claimed |
| US-4168984-A | ADDING A GLYCOL ACETATE | MARTIN MARIETTA CORPORATION (US) | 1979-09-25 | — | — | US | claimed |