Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 4/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | KHK | P50053 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3601240 | 1.00 | KDM4E (0.49) | KDM4EALDH1A1LMNAHSD17B10KDR | |
| SCHEMBL3602181 | 0.93 | KDM4E (0.53) | KDM4EALDH1A1LMNAHSD17B10KDR | |
| SCHEMBL3598914 | 0.93 | KDM4E (0.53) | KDM4EALDH1A1LMNAHSD17B10KDR | |
| SCHEMBL3598920 | 0.93 | KDM4E (0.53) | KDM4EALDH1A1LMNAHSD17B10KDR | |
| Trifluoroacetic Acid SCHEMBL3606654 | 0.86 | KDR (0.52) | KDM4EALDH1A1LMNAKDRMLLT1 | |
| Trifluoroacetic Acid SCHEMBL3612189 | 0.84 | ALB (0.47) | KDRPARP1HDAC4SMYD3HDAC6 | |
| Trifluoroacetic Acid SCHEMBL3606633 | 0.84 | ALB (0.47) | KDRPARP1HDAC4SMYD3HDAC6 | |
| Trifluoroacetic Acid SCHEMBL3595860 | 0.83 | CDK5 (0.46) | KDRJAK2PARP1HDAC4SMYD3 | |
| Trifluoroacetic Acid SCHEMBL3605047 | 0.83 | CDK5 (0.46) | KDRJAK2PARP1HDAC4SMYD3 | |
| Trifluoroacetic Acid SCHEMBL3601873 | 0.80 | DRD4 (0.46) | KDRMLLT1PARP1HDAC4SMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | IDO2, IDO1, INMT | KDM4E 963/4885ALDH1A1 513/4885LMNA 3287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.