Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.49 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3599741 | 0.85 | KMT2A (0.52) | SMN1; SMN2KMT2ATSHRHTTGAA | |
| SCHEMBL21333264 | 0.84 | SMN1; SMN2 (0.67) | SMN1; SMN2KMT2ALMNANPC1ALDH1A1 | |
| SCHEMBL21332805 | 0.83 | SMN1; SMN2 (0.77) | SMN1; SMN2KMT2ALMNANPC1ALDH1A1 | |
| SCHEMBL30739049 | 0.77 | SMN1; SMN2 (0.58) | SMN1; SMN2KMT2ALMNANPC1ALDH1A1 | |
| SCHEMBL3610766 | 0.76 | TEAD2 (0.52) | SMN1; SMN2KMT2ALMNAALDH1A1CYP4F2 | |
| SCHEMBL3606832 | 0.76 | SMN1; SMN2 (0.57) | SMN1; SMN2KMT2ALMNAALDH1A1CYP4F2 | |
| SCHEMBL13462878 | 0.75 | SMN1; SMN2 (0.58) | SMN1; SMN2KMT2ALMNANPC1ALDH1A1 | |
| SCHEMBL16166249 | 0.75 | NPC1 (0.83) | SMN1; SMN2KMT2ALMNANPC1ALDH1A1 | |
| SCHEMBL6664950 | 0.74 | SMN1; SMN2 (0.56) | SMN1; SMN2KMT2ALMNANPC1ALDH1A1 | |
| SCHEMBL12876310 | 0.74 | MAPT (0.47) | SMN1; SMN2KMT2ALMNANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100041696-A1 | Compounds | SMITHKLINE BEECHAM CORPORATION | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041696-A1 | Compounds | CYP11B2, SCD, CYP3A5 | SMN1; SMN2 618/4885KMT2A 3500/4885LMNA 1551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.