Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenelzine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA known ✓ | P21397 | 2/20 | 0.91 |
| ▸ | MAOB known ✓ | P27338 | 2/20 | 0.91 |
| ▸ | LMNA | P02545 | 3/20 | 0.91 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.91 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.91 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.91 |
| ▸ | IDO1 | P14902 | 2/20 | 0.91 |
| ▸ | KDM1A | O60341 | 2/20 | 0.91 |
| ▸ | NPC1 | O15118 | 2/20 | 0.91 |
| ▸ | RAB9A | P51151 | 2/20 | 0.91 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.91 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.91 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.91 |
| ▸ | HTR1A | P08908 | 1/20 | 0.91 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.91 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.91 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.91 |
| ▸ | TSHR | P16473 | 1/20 | 0.91 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.91 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.91 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenelzine SCHEMBL34335 | 0.95 | LMNA (1.00) | LMNACYP3A4SMN1; SMN2ALDH1A1IDO1 | |
| Phenelzine SCHEMBL3644150 | 0.95 | LMNA (1.00) | LMNACYP3A4SMN1; SMN2ALDH1A1IDO1 | |
| Phenelzine SCHEMBL6064850 | 0.93 | LMNA (0.95) | LMNACYP3A4SMN1; SMN2ALDH1A1IDO1 | |
| Phenelzine SCHEMBL21084303 | 0.93 | LMNA (0.95) | LMNACYP3A4SMN1; SMN2ALDH1A1IDO1 | |
| Phenelzine SCHEMBL2786042 | 0.93 | CYP3A4 (0.95) | LMNACYP3A4SMN1; SMN2ALDH1A1IDO1 | |
| Phenelzine SCHEMBL118234 | 0.93 | CYP3A4 (0.95) | LMNACYP3A4SMN1; SMN2ALDH1A1IDO1 | |
| Phenelzine SCHEMBL3243562 | 0.83 | LMNA (1.00) | LMNACYP3A4SMN1; SMN2ALDH1A1IDO1 | |
| Phenelzine SCHEMBL40652 | 0.83 | LMNA (1.00) | LMNACYP3A4SMN1; SMN2ALDH1A1IDO1 | |
| Phenelzine SCHEMBL5072466 | 0.83 | LMNA (1.00) | LMNACYP3A4SMN1; SMN2ALDH1A1IDO1 | |
| Phenelzine SCHEMBL6428409 | 0.82 | ALDH1A1 (0.83) | LMNACYP3A4SMN1; SMN2ALDH1A1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230111917-A1 | KINASE ANTAGONISTS | UNIV CALIFORNIA (US) | 2023-04-13 | — | — | US | disclosed |
| EP-2551270-B1 | PYRAZOLOPYRIMIDINE DERIVATIVES FOR USE AS PI3 KINASE ANTAGONISTS | UNIV CALIFORNIA (US) | 2019-06-12 | — | — | EP | disclosed |
| US-8642604-B2 | Substituted pyrazolo[3,2-d]pyrimidines as anti-cancer agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-02-04 | — | — | US | disclosed |
| EP-2004654-B1 | PYRAZOLOPYRIMIDINE DERIVATIVES FOR USE AS KINASE ANTAGONISTS | UNIV CALIFORNIA (US) | 2013-05-22 | — | — | EP | disclosed |
| EP-2551270-A2 | PYRAZOLOPYRMIDINE DERIVATIVES FOR USE AS PI3 KINASE ANTAGONISTS | The Regents of The University of California (US) | 2013-01-30 | — | — | EP | disclosed |
| US-20110301144-A1 | Kinase Antagonists | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-12-08 | — | — | US | disclosed |
| US-20100009963-A1 | KINASE ANTAGONISTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-01-14 | — | — | US | disclosed |
| US-7585868-B2 | Substituted pyrazolo[3,4-D]pyrimidines as kinase antagonists | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-09-08 | — | — | US | disclosed |
| EP-2004654-A2 | KINASE ANTAGONISTS | The Regents of the University of California (US) | 2008-12-24 | — | — | EP | disclosed |
| US-20070293516-A1 | Antagonists of a lipid kinase such as a PI3 kinase, protein tyrosine kinase, and/or protein serine-threonine kinases such as mTOR; 1-isopropyl-3-(3-methoxy-4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-12-20 | — | — | US | disclosed |
| WO-2007114926-A2 | KINASE ANTAGONISTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293516-A1 | Antagonists of a lipid kinase such as a PI3 kinase, protein tyrosine kinase, and/or protein serine-threonine kinases such as mTOR; 1-isopropyl-3-(3-methoxy-4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | MTOR, PI4KA, PIK3CA | MAOA 2544/4885MAOB 2808/4885LMNA 4705/4885 |
| US-20230111917-A1 | KINASE ANTAGONISTS | MTOR, RPS6KA3, AKT3 | MAOA 4006/4885MAOB 3886/4885LMNA 4806/4885 |
| US-20100009963-A1 | KINASE ANTAGONISTS | MTOR, RPS6KA3, AKT3 | MAOA 4006/4885MAOB 3886/4885LMNA 4806/4885 |
| US-20110301144-A1 | Kinase Antagonists | MTOR, RPS6KA3, AKT3 | MAOA 4006/4885MAOB 3886/4885LMNA 4806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.