Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | TMPRSS2 | O15393 | 3/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.38 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13945301 | 0.86 | KDM1A (0.52) | ESR2TMPRSS2KDM1ANPC1RAB9A | |
| SCHEMBL3606619 | 0.85 | TMPRSS2 (0.49) | ESR2TMPRSS2KDM1ANPC1RAB9A | |
| SCHEMBL3600668 | 0.85 | ESR2 (0.46) | ESR2TMPRSS2NPC1RAB9ANOD1 | |
| SCHEMBL3596504 | 0.81 | SMN1; SMN2 (0.57) | ESR2TMPRSS2KDM1ANOD1MEN1 | |
| Hydrochloric Acid SCHEMBL3591953 | 0.78 | USP28 (0.45) | NPC1RAB9AMEN1KMT2ASCD5 | |
| SCHEMBL3728485 | 0.78 | ESR2 (0.47) | ESR2TMPRSS2KDM1ANPC1RAB9A | |
| SCHEMBL3184449 | 0.77 | PTGER1 (0.49) | ESR2TMPRSS2KDM1ANOD1NR1H2 | |
| SCHEMBL6646767 | 0.76 | ESR2 (0.55) | ESR2TMPRSS2NPC1RAB9ANR1H2 | |
| SCHEMBL3603275 | 0.76 | NAMPT (0.49) | ESR2TMPRSS2KDM1ANPC1RAB9A | |
| SCHEMBL13844972 | 0.75 | SCD (0.51) | ESR2KDM1AMEN1KMT2ASCD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100041696-A1 | Compounds | SMITHKLINE BEECHAM CORPORATION | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041696-A1 | Compounds | CYP11B2, SCD, CYP3A5 | ESR2 3025/4885TMPRSS2 2074/4885KDM1A 2299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.