Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 7/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | ROS1 | P08922 | 2/20 | 0.45 |
| ▸ | FLT1 | P17948 | 2/20 | 0.45 |
| ▸ | FLT4 | P35916 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.45 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.45 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | PRKCG | P05129 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | FES | P07332 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | FER | P16591 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3600660 | 0.88 | ROCK1 (0.50) | TNIKROCK1JAK2MAP4K4ROS1 | |
| SCHEMBL3601935 | 0.85 | TNIK (0.42) | TNIKROCK1JAK2MAP4K4ROS1 | |
| SCHEMBL3604802 | 0.82 | ROCK1 (0.48) | ROCK1MAP4K4FLT4KDRFLT3 | |
| SCHEMBL3603801 | 0.80 | CCNT1 (0.48) | TNIKROCK1ROCK2CHRNA7 | |
| SCHEMBL27819463 | 0.79 | TNIK (0.50) | TNIKROCK1MAP4K4FLT4KDR | |
| SCHEMBL3610309 | 0.78 | ROCK1 (0.60) | ROCK1JAK2MAP4K4FLT4KDR | |
| SCHEMBL3609665 | 0.77 | CD274 (0.60) | ROCK1JAK2MAP4K4ROS1FLT1 | |
| SCHEMBL3602313 | 0.75 | PRKG1 (0.64) | TNIKROCK1MAP4K4FLT4KDR | |
| SCHEMBL3602589 | 0.71 | ROCK1 (0.50) | ROCK1MAP4K4FLT4KDRFLT3 | |
| SCHEMBL3595639 | 0.69 | CDK9 (0.46) | ROCK1MAP4K4FLT4KDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035919-A1 | COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASES | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035919-A1 | COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASES | ROCK1, ROCK2, RHOA | TNIK 469/4885ROCK1 1/4885JAK2 239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.