Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | ETV6 | P41212 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3609800 | 0.90 | PTGS2 (0.43) | CNR2PTGS2PTGS1CRHR1ABCC4 | |
| SCHEMBL896318 | 0.88 | CNR2 (0.37) | CNR2NPC1PTGS2PTGS1CRHR1 | |
| SCHEMBL3616326 | 0.85 | MEN1 (0.36) | CNR2NPC1PTGS2PTGS1CRHR1 | |
| SCHEMBL10000738 | 0.84 | CNR2 (0.35) | CNR2NPC1PTGS2PTGS1CRHR1 | |
| SCHEMBL10000761 | 0.84 | MAOB (0.40) | CNR2PTGS2PTGS1CRHR1KMT2A | |
| SCHEMBL3619780 | 0.83 | IDO1 (0.37) | CNR2PTGS2PTGS1CRHR1ABCC4 | |
| SCHEMBL3569381 | 0.78 | CNR2 (0.42) | CNR2PTGS2PTGS1NOTUMKDM4E | |
| SCHEMBL10000192 | 0.77 | CNR2 (0.37) | CNR2NPC1PTGS2PTGS1CRHR1 | |
| SCHEMBL15886463 | 0.77 | GRIN1 (0.45) | MEN1KMT2AKDM4E | |
| SCHEMBL13092765 | 0.76 | KMT2A (0.37) | CNR2MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029668-A1 | NOVEL PYRIDAZINE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-02-04 | — | — | US | claimed |
| EP-2049521-A2 | NOVEL PYRIDAZINE DERIVATIVES | Syngeta Participations AG (CH) | 2009-04-22 | — | — | EP | claimed |
| WO-2008009405-A2 | NOVEL PYRIDAZINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-01-24 | — | — | WO | claimed |
| US-20100029668-A1 | NOVEL PYRIDAZINE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-02-04 | — | — | US | disclosed |
| EP-2049521-A2 | NOVEL PYRIDAZINE DERIVATIVES | Syngeta Participations AG (CH) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008009405-A2 | NOVEL PYRIDAZINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029668-A1 | NOVEL PYRIDAZINE DERIVATIVES | C3AR1, C5, C1S | CNR2 215/4885NPC1 2554/4885PTGS2 2167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.