Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TFPI2 | P48307 | 1/20 | 0.45 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.44 |
| ▸ | KHK | P50053 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7267718 | 0.78 | ALDH1A1 (0.55) | HTR4MAPK1 | |
| Hydrochloric Acid SCHEMBL7443261 | 0.77 | ALDH1A1 (0.54) | HTR4MAPK1 | |
| SCHEMBL3604401 | 0.77 | KDM1A (0.37) | HTR4KHKKDM1AKDRTLR9 | |
| SCHEMBL23931088 | 0.73 | MAPK1 (0.39) | HTR4KDM1AACSS2MAPK1 | |
| SCHEMBL8528870 | 0.72 | TFPI2 (0.47) | TFPI2RAB9AMEN1KMT2A | |
| SCHEMBL8527700 | 0.72 | MEN1 (0.46) | TFPI2MEN1KMT2A | |
| SCHEMBL27887683 | 0.69 | TFPI2 (0.51) | TFPI2RAB9AMEN1KMT2AHTR6 | |
| Hydrochloric Acid SCHEMBL4937740 | 0.69 | NPC1 (0.62) | RAB9AMEN1KMT2A | |
| SCHEMBL887130 | 0.67 | CREBBP (0.55) | TFPI2RAB9AMEN1KMT2A | |
| SCHEMBL30622597 | 0.67 | TFPI2 (0.54) | TFPI2MEN1KMT2AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | IDO2, IDO1, INMT | TFPI2 2746/4885HTR4 247/4885KHK 2769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.