⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1187892 | 0.68 | — | — | |
| SCHEMBL2405291 | 0.68 | — | — | |
| SCHEMBL7532803 | 0.68 | — | — | |
| SCHEMBL31604210 | 0.68 | — | — | |
| SCHEMBL3661961 | 0.67 | CES2 (0.37) | — | |
| SCHEMBL9812785 | 0.67 | — | — | |
| SCHEMBL7796741 | 0.67 | — | — | |
| SCHEMBL10866789 | 0.65 | — | — | |
| SCHEMBL546936 | 0.64 | PTPN1 (0.39) | — | |
| SCHEMBL7267662 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777663-B1 | USE OF SUBSTITUTED 6-AMINO-4H-PYRANS | BAYER AG (DE) | 1999-05-26 | — | — | EP | claimed |
| EP-2935214-B1 | 1,4-PYRIDONE COMPOUNDS | EPIZYME INC (US) | 2019-02-20 | — | — | EP | disclosed |
| US-10150759-B2 | 1,4-pyridone bicycic heteroaryl compounds | Epizyme, Inc. (US) | 2018-12-11 | — | — | US | disclosed |
| US-20180134692-A1 | 1,4-PYRIDONE BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. | 2018-05-17 | — | — | US | disclosed |
| EP-2935264-B1 | 1,4-PYRIDONE BICYCLIC HETEROARYL COMPOUNDS | EPIZYME INC (US) | 2017-10-18 | — | — | EP | disclosed |
| US-9701666-B2 | 1,4-pyridone bicyclic heteroaryl compounds | Epizyme, Inc. (US) | 2017-07-11 | — | — | US | disclosed |
| US-20150344459-A1 | 1,4-PYRIDONE BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. | 2015-12-03 | — | — | US | disclosed |
| US-20150344427-A1 | 1,4-PYRIDONE COMPOUNDS | Epizyme, Inc. (US) | 2015-12-03 | — | — | US | disclosed |
| EP-2935264-A1 | 1,4-PYRIDONE BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. (US) | 2015-10-28 | — | — | EP | disclosed |
| EP-2935214-A1 | 1,4-PYRIDONE COMPOUNDS | Epizyme, Inc. (US) | 2015-10-28 | — | — | EP | disclosed |
| WO-2014100665-A1 | 1,4-PYRIDONE BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. (US) | 2014-06-26 | — | — | WO | disclosed |
| US-7674823-B2 | DNA-PK inhibitors | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2010-03-09 | — | — | US | disclosed |
| US-20070238729-A1 | DNA-PK INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2007-10-11 | — | — | US | disclosed |
| US-7226918-B2 | DNA-PK inhibitors | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2007-06-05 | — | — | US | disclosed |
| US-20040192687-A1 | Dna-pk inhibitors | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2004-09-30 | — | — | US | disclosed |
| EP-1417196-A1 | DNA-PK INHIBITORS | Cancer Research Technology Limited (GB) | 2004-05-12 | — | — | EP | disclosed |
| WO-2003024949-A1 | DNA-PK INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2003-03-27 | — | — | WO | disclosed |
| EP-0777663-B1 | USE OF SUBSTITUTED 6-AMINO-4H-PYRANS | BAYER AG (DE) | 1999-05-26 | — | — | EP | disclosed |
| EP-0777663-A1 | USE OF SUBSTITUTED 6-AMINO-4H-PYRANS | BAYER AG (DE) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996006091-A1 | USE OF SUBSTITUTED 6-AMINO-4H-PYRANS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-02-29 | — | — | WO | disclosed |