Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 16/20 | 0.67 |
| ▸ | CHUK | O15111 | 16/20 | 0.67 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | NEK1 | Q96PY6 | 5/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | AURKAIP1 | Q9NWT8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3417460 | 0.94 | IKBKB (0.70) | IKBKBCHUKROCK1CYP2C9NEK1 | |
| SCHEMBL3416205 | 0.92 | IKBKB (0.76) | IKBKBCHUKROCK1CYP2C9NEK1 | |
| SCHEMBL3607022 | 0.87 | IKBKB (0.58) | IKBKBCHUKROCK1CYP2C9NEK1 | |
| Trifluoroacetic Acid SCHEMBL3414611 | 0.86 | IKBKB (0.86) | IKBKBCHUKROCK1CYP2C9NEK1 | |
| Trifluoroacetic Acid SCHEMBL3417480 | 0.86 | IKBKB (0.90) | IKBKBCHUKROCK1CYP2C9NEK1 | |
| Trifluoroacetic Acid SCHEMBL3411915 | 0.86 | IKBKB (0.85) | IKBKBCHUKROCK1CYP2C9NEK1 | |
| Trifluoroacetic Acid SCHEMBL3412847 | 0.85 | IKBKB (0.74) | IKBKBCHUKROCK1CYP2C9NEK1 | |
| Trifluoroacetic Acid SCHEMBL3414006 | 0.85 | IKBKB (0.60) | IKBKBCHUKROCK1CYP2C9NEK1 | |
| Trifluoroacetic Acid SCHEMBL3412089 | 0.85 | IKBKB (0.70) | IKBKBCHUKROCK1CYP2C9NEK1 | |
| SCHEMBL3413342 | 0.84 | IKBKB (0.59) | IKBKBCHUKROCK1CYP2C9NEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035917-A1 | PYRROLO[2,3-B]PYRIDIN-4-YL-BENZENESULFONAMIDE COMPOUNDS AS 1KK2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2010-02-11 | — | — | US | disclosed |
| US-20080176891-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-07-24 | — | — | US | disclosed |
| US-20080146606-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176891-A1 | NOVEL COMPOUNDS | NFKBIA, IKBKG, IKBKE | IKBKB 4/4885CHUK 8/4885ROCK1 467/4885 |
| US-20100035917-A1 | PYRROLO[2,3-B]PYRIDIN-4-YL-BENZENESULFONAMIDE COMPOUNDS AS 1KK2 INHIBITORS | PLK2, PDXK, MAP4K2 | IKBKB 428/4885CHUK 300/4885ROCK1 550/4885 |
| US-20080146606-A1 | NOVEL COMPOUNDS | NFKBIA, IKBKG, IKBKE | IKBKB 4/4885CHUK 8/4885ROCK1 467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.