Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 8/20 | 0.65 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.65 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | THPO | P40225 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.48 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1497179 | 0.95 | ADORA2B (0.57) | ADORA2BADORA1ADORA2AADORA3PDE5A | |
| SCHEMBL1497236 | 0.90 | ADORA2B (0.63) | ADORA2BADORA1ADORA2AADORA3KDM4E | |
| SCHEMBL1497292 | 0.85 | ADORA2B (0.47) | ADORA2BADORA1ADORA2AADORA3KDM4E | |
| SCHEMBL1497260 | 0.85 | ADORA2B (0.56) | ADORA2BADORA1ADORA2AADORA3KDM4E | |
| SCHEMBL1497281 | 0.84 | ADORA2B (0.48) | ADORA2BADORA1ADORA2AADORA3KDM4E | |
| SCHEMBL1497254 | 0.83 | ADORA2B (0.57) | ADORA2BADORA1ADORA2AKDM4EALDH1A1 | |
| SCHEMBL1497235 | 0.83 | ADORA2B (0.65) | ADORA2BADORA1ADORA2AADORA3KDM4E | |
| SCHEMBL1497250 | 0.81 | ADORA2B (0.52) | ADORA2BADORA1ADORA2AADORA3KDM4E | |
| SCHEMBL1497246 | 0.81 | ADORA2B (0.62) | ADORA2BADORA1ADORA2AADORA3KDM4E | |
| SCHEMBL1497230 | 0.81 | ADORA2B (0.62) | ADORA2BADORA1ADORA2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658291-B1 | SUBSTITUTED 8-HETEROARYL XANTHINES | DOGWOOD PHARMACEUTICALS INC (US) | 2013-10-02 | — | — | EP | claimed |
| US-20100273780-A1 | SUBSTITUTED 8-HETEROARYL XANTHINES | PGXHEALTH, LLC (US) | 2010-10-28 | — | — | US | claimed |
| CN-1894250-B | Substituted 8-heteroaryl xanthines | ADENOSINE THERAPEUTICS LLC | 2010-06-09 | — | — | CN | claimed |
| CN-1894250-A | Substituted 8-heteroaryl xanthines | ADENOSINE THERAPEUTICS LLC (US) | 2007-01-10 | — | — | CN | claimed |
| EP-2295434-B1 | Substituted 8-heteroaryl xanthines | DOGWOOD PHARMACEUTICALS INC (US) | 2015-09-30 | — | — | EP | disclosed |
| EP-1658291-B1 | SUBSTITUTED 8-HETEROARYL XANTHINES | DOGWOOD PHARMACEUTICALS INC (US) | 2013-10-02 | — | — | EP | disclosed |
| CN-101851238-B | Substituted 8-heteroaryl xanthines | ADENOSINE THERAPEUTICS LLC | 2012-07-18 | — | — | CN | disclosed |
| CN-101851238-A | The 8-heteroaryl xanthine that replaces | ADENOTHERAPEUTICS LLC | 2010-10-06 | — | — | CN | disclosed |
| CN-1894250-B | Substituted 8-heteroaryl xanthines | ADENOSINE THERAPEUTICS LLC | 2010-06-09 | — | — | CN | disclosed |
| CN-1894250-A | Substituted 8-heteroaryl xanthines | ADENOSINE THERAPEUTICS LLC (US) | 2007-01-10 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273780-A1 | SUBSTITUTED 8-HETEROARYL XANTHINES | ADORA2B, ADORA2A, ADORA3 | ADORA2B 1/4885ADORA1 4/4885ADORA2A 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.