Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 6/20 | 1.00 |
| ▸ | TYMS | P04818 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3605275 | 0.81 | DHFR (0.74) | DHFRTYMSMEN1LMNAMAPT | |
| SCHEMBL3600979 | 0.81 | DHFR (0.74) | DHFRTYMSMEN1LMNAMAPT | |
| SCHEMBL649476 | 0.81 | DHFR (0.67) | DHFRTYMSALDH1A1ALOX15HSD17B10 | |
| SCHEMBL6652633 | 0.76 | TYMS (0.61) | DHFRTYMSALDH1A1ALOX15TSHR | |
| SCHEMBL3378483 | 0.75 | TYMS (0.61) | DHFRTYMSALDH1A1ALOX15TSHR | |
| SCHEMBL14894102 | 0.75 | DHFR (0.59) | DHFRTYMSALDH1A1ALOX15TSHR | |
| SCHEMBL14481559 | 0.75 | DHFR (0.59) | DHFRTYMSALDH1A1ALOX15TSHR | |
| SCHEMBL4635984 | 0.75 | DHFR (0.59) | DHFRTYMSALDH1A1ALOX15TSHR | |
| SCHEMBL6815170 | 0.75 | TYMS (0.59) | DHFRTYMSALDH1A1ALOX15TSHR | |
| SCHEMBL23992333 | 0.74 | DHFR (0.59) | DHFRTYMSALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100048692-A1 | Naphthofuranone Derivatives as Specific Inhibitors of Thymidylate Synthases | TYDOCKPHARMA S.R.L. (IT) | 2010-02-25 | — | — | US | claimed |
| US-20100048692-A1 | Naphthofuranone Derivatives as Specific Inhibitors of Thymidylate Synthases | TYDOCKPHARMA S.R.L. (IT) | 2010-02-25 | — | — | US | disclosed |
| EP-2044047-A1 | NAPHTHOFURANONE DERIVATIVES AS SPECIFIC INHIBITORS OF THYMIDYLATE SYNTHASES | TydockPharma S.r.l. (IT) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008003510-A1 | NAPHTHOFURANONE DERIVATIVES AS SPECIFIC INHIBITORS OF THYMIDYLATE SYNTHASES | TYDOCKPHARMA S.R.L. (IT) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048692-A1 | Naphthofuranone Derivatives as Specific Inhibitors of Thymidylate Synthases | TYMS, TYMP, DNTT | DHFR 12/4885TYMS 1/4885ALDH1A1 1436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.