Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 13/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3595651 | 0.99 | CRHR1 (0.41) | DPP4DPP8CRHR1CNR1HSD11B1 | |
| SCHEMBL3601942 | 0.88 | DPP4 (0.38) | DPP4DPP8CRHR1CNR1HSD11B1 | |
| SCHEMBL3601200 | 0.88 | TP53 (0.38) | DPP4DPP8CRHR1HSD11B1 | |
| SCHEMBL3599359 | 0.85 | CXCR2 (0.40) | DPP4DPP8CNR1HSD11B1 | |
| SCHEMBL3600935 | 0.85 | TP53 (0.45) | DPP4DPP8CRHR1HSD11B1 | |
| SCHEMBL3597273 | 0.84 | CXCR2 (0.40) | DPP4DPP8CNR1HSD11B1 | |
| SCHEMBL3604507 | 0.82 | DPP4 (0.47) | DPP4DPP8CRHR1CNR1HSD11B1 | |
| SCHEMBL3594733 | 0.81 | CXCR2 (0.44) | DPP4DPP8CNR1HSD11B1 | |
| SCHEMBL3599200 | 0.81 | DPP4 (0.46) | DPP4DPP8CRHR1CNR1HSD11B1 | |
| SCHEMBL3600919 | 0.81 | MDM4 (0.42) | DPP4DPP8CNR1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728146-B2 | Enzyme inhibitors | PROBIODRUG AG (DE) | 2010-06-01 | — | — | US | claimed |