Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.31 |
| ▸ | MIF | P14174 | 1/20 | 0.31 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13165465 | 0.87 | KCNJ1 (0.52) | KCNJ1ALDH1A1SIRT6MAPK1P4HA1 | |
| SCHEMBL15305157 | 0.78 | KDM4E (0.48) | KCNJ1ALDH1A1SIRT6HPGDALOX15 | |
| Hydrochloric Acid SCHEMBL29202159 | 0.76 | KDM4E (0.46) | KCNJ1ALDH1A1SIRT6HPGDALOX15 | |
| SCHEMBL21477593 | 0.76 | KCNJ1 (0.44) | KCNJ1ALDH1A1SIRT6MAPK1P4HA1 | |
| SCHEMBL29526226 | 0.76 | KCNJ1 (0.44) | KCNJ1ALDH1A1SIRT6HPGDMAPK1 | |
| SCHEMBL30091932 | 0.76 | POLB (0.50) | KCNJ1ALDH1A1HPGDPOLBKDM4E | |
| SCHEMBL29202158 | 0.76 | KCNJ1 (0.44) | KCNJ1ALDH1A1SIRT6MAPK1P4HA1 | |
| SCHEMBL5041030 | 0.76 | SIRT6 (0.59) | KCNJ1ALDH1A1SIRT6P4HA1MIF | |
| SCHEMBL3608095 | 0.76 | KCNJ1 (0.44) | KCNJ1ALDH1A1SIRT6HPGDMAPK1 | |
| SCHEMBL1608749 | 0.76 | POLB (0.50) | KCNJ1ALDH1A1HPGDPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7754743-B2 | Heteroarylcarbamoylbenzene derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-07-13 | — | — | US | disclosed |
| US-20090018056-A1 | Heteroarylcarbamoylbenzene derivatives | MSD K.K. (JP) | 2009-01-15 | — | — | US | disclosed |
| US-7432287-B2 | Heteroarylcarbamoylbenzene derivative | BANYU PHARMECEUTICAL CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |
| US-20060167053-A1 | Heteroarylcarbamoylbenzene derivative | MSD K.K. (JP) | 2006-07-27 | — | — | US | disclosed |
| EP-1600442-A1 | HETEROARYLCARBAMOYLBENZENE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2005-11-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018056-A1 | Heteroarylcarbamoylbenzene derivatives | GCK, GCKR, KHK | KCNJ1 93/4885ALDH1A1 707/4885SIRT6 760/4885 |
| US-20060167053-A1 | Heteroarylcarbamoylbenzene derivative | GCK, GCKR, GALK1 | KCNJ1 355/4885ALDH1A1 902/4885SIRT6 885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.