Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 3/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL360969 | 0.86 | MEN1 (0.36) | MEN1KMT2APOLBADRB2ALDH1A1 | |
| SCHEMBL362961 | 0.82 | GPR119 (0.41) | KMT2ALMNAKDM1A | |
| SCHEMBL362106 | 0.82 | POLB (0.35) | MEN1KMT2APOLBADRB2ALDH1A1 | |
| SCHEMBL14876636 | 0.81 | KDM1A (0.38) | MEN1KMT2AALDH1A1KDM4EKDM1A | |
| SCHEMBL15110449 | 0.70 | GPR119 (0.41) | KMT2ALMNAKDM1A | |
| SCHEMBL15110882 | 0.69 | KDM1A (0.38) | MEN1KMT2AALDH1A1LMNAMAPK1 | |
| SCHEMBL5804495 | 0.65 | TARBP2 (0.44) | POLBALDH1A1LMNAMAPK1ADORA3 | |
| SCHEMBL15110494 | 0.64 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1 | |
| SCHEMBL8482742 | 0.63 | KDM5C (0.56) | MEN1KMT2APOLBADRB2ALDH1A1 | |
| SCHEMBL14876725 | 0.63 | ALDH1A1 (0.38) | ALDH1A1KDM4EKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593452-A1 | IP RECEPTOR AGONIST HETEROCYCLIC COMPOUNDS | Novartis AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007539-A9 | IP RECEPTOR AGONIST HETEROCYCLIC COMPOUNDS | NOVARTIS AG (CH) | 2012-11-01 | — | — | WO | disclosed |
| WO-2012007539-A1 | IP RECEPTOR AGONIST HETEROCYCLIC COMPOUNDS | NOVARTIS AG (CH) | 2012-01-19 | — | — | WO | disclosed |