Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | BCR | P11274 | 1/20 | 0.49 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | NGFR | P08138 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | F7 | P08709 | 1/20 | 0.46 |
| ▸ | F3 | P13726 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19329742 | 0.85 | HRH4 (0.56) | HRH4FLT3NGFRKDM4EHPGD | |
| SCHEMBL1333512 | 0.85 | SMAD3 (0.66) | HRH4CYP2A6KEAP1PDGFRBFLT3 | |
| SCHEMBL12862877 | 0.84 | HRH4 (0.58) | HRH4CYP2A6KEAP1PDGFRBFLT3 | |
| SCHEMBL3282981 | 0.81 | FLT3 (0.73) | HRH4PDGFRBFLT3ABL1KIT | |
| SCHEMBL1651087 | 0.81 | MMP2 (0.66) | HRH4PDGFRBFLT3ABL1KIT | |
| SCHEMBL12086506 | 0.80 | HRH4 (0.55) | HRH4PDGFRBFLT3ABL1KIT | |
| SCHEMBL764543 | 0.80 | F7 (0.72) | HRH4FLT3F7F3DAO | |
| SCHEMBL250527 | 0.80 | KDM4E (0.72) | HRH4FLT3KDM4EHPGDHSD17B10 | |
| SCHEMBL1156450 | 0.80 | FLT3 (0.57) | HRH4PDGFRBFLT3ABL1KIT | |
| SCHEMBL11960184 | 0.80 | PIN1 (0.72) | HRH4PDGFRBFLT3MMP2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4676912-A2 | COMPOUNDS, COMPOSITIONS, AND METHOD OF INHIBITING TAU PROTEIN AND ALPHA-SYNUCLEIN AGGREGATION | Purdue Research Foundation (US) | 2026-01-14 | — | — | EP | disclosed |
| WO-2024206127-A2 | COMPOUNDS, COMPOSITIONS, AND METHOD OF INHIBITING TAU PROTEIN AND ALPHA-SYNUCLEIN AGGREGATION | PURDUE RESEARCH FOUNDATION (US) | 2024-10-03 | — | — | WO | disclosed |
| US-7723325-B2 | 5-amido-indole-2-carboxamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2010-05-25 | — | — | US | disclosed |
| US-7601711-B2 | Such as [5-(4-cyclopentyl-piperazine-1-carbonyl)-1H-indol-2-yl]-morpholin-4-yl-methanone; histamine H3-antagonists | HOFFMANN-LA ROCHE INC. (US) | 2009-10-13 | — | — | US | disclosed |
| CN-101421235-A | 5-amido-2-amide indoles | HOFFMANN LA ROCHE (CH) | 2009-04-29 | — | — | CN | disclosed |
| CN-101421235-A | 5-amido-2-amide indoles | HOFFMANN LA ROCHE (CH) | 2009-04-29 | — | — | CN | disclosed |
| US-20070244125-A1 | 5-amido-indole-2-carboxamide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244125-A1 | 5-amido-indole-2-carboxamide derivatives | HRH4, HRH3, CNR2 | HRH4 1/4885CYP2A6 571/4885KEAP1 3614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.