Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTR6 | P50406 | 6/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4022768 | 0.93 | KDM4E (0.42) | KDM4EALDH1A1HTR6CYP2D6CYP3A4 | |
| SCHEMBL3623475 | 0.92 | HTR6 (0.53) | KDM4EALDH1A1HTR6CYP2D6CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL3623208 | 0.92 | HTR6 (0.56) | KDM4EALDH1A1HTR6CYP2D6CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL4016534 | 0.87 | HTR6 (0.51) | KDM4EALDH1A1HTR6CYP2D6CYP3A4 | |
| SCHEMBL3620812 | 0.85 | KDM4E (0.52) | KDM4EALDH1A1HTR6CYP2D6CYP3A4 | |
| SCHEMBL3625769 | 0.83 | HTR6 (0.64) | KDM4EALDH1A1HTR6CYP2D6CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL3616912 | 0.83 | HTR6 (0.50) | KDM4EALDH1A1HTR6CYP2D6CYP3A4 | |
| SCHEMBL3622607 | 0.83 | HTR6 (0.48) | KDM4EALDH1A1HTR6CYP2D6CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL3624799 | 0.80 | HTR6 (0.51) | KDM4EALDH1A1HTR6CYP2D6CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL3617270 | 0.80 | HTR6 (0.68) | HTR6CYP2D6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046741-B1 | INDOLES AS 5-HT6 MODULATORS | PROXIMAGEN LTD (GB) | 2012-10-31 | — | — | EP | disclosed |
| US-7812017-B2 | 4-substituted indole and indoline compounds | BIOVITRUM AB (PUBL.) (SE) | 2010-10-12 | — | — | US | disclosed |
| US-20080032968-A1 | New compounds | PROXIMAGEN NEUROSCIENCE PLC (GB) | 2008-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080032968-A1 | New compounds | HTR6, HTR1B, HTR1A | KDM4E 3665/4885ALDH1A1 917/4885HTR6 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.