⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2403062 | 0.80 | ALDH1A1 (0.42) | — | |
| SCHEMBL39666 | 0.80 | — | — | |
| Water SCHEMBL1276018 | 0.78 | — | — | |
| Bromide SCHEMBL4252005 | 0.78 | — | — | |
| SCHEMBL15870899 | 0.74 | RIOK2 (0.49) | — | |
| SCHEMBL9110463 | 0.73 | — | — | |
| SCHEMBL4077175 | 0.70 | — | — | |
| SCHEMBL14629165 | 0.70 | — | — | |
| SCHEMBL3428422 | 0.70 | — | — | |
| SCHEMBL21219440 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106998685-A | 14-membered ketolides and methods of making and using the same | 哈佛大学的校长及成员们 | 2017-08-01 | — | — | CN | claimed |
| CN-105246334-A | Macrolides and methods of making and using the same | HARVARD COLLEGE | 2016-01-13 | — | — | CN | claimed |
| CN-105218516-A | Therapeutic compounds and related methods of use | OTSUKA PHARMA CO LTD | 2016-01-06 | — | — | CN | claimed |
| CN-102883723-A | Therapeutic compounds and related methods of use | GALENEA CORP | 2013-01-16 | — | — | CN | claimed |
| US-8067419-B2 | N-[(S)-1-benzyl-2-(4-benzyl-piperazin-1-yl)-2-oxo-ethyl]-N-(4-pentyl-benzyl)-3-(4-trifluoromethyl-phenyl)-acrylamide, for example; antiprotozoa agents | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-11-29 | — | — | US | claimed |
| CN-100549011-C | Novel imidazopyridine as cell cycle protein dependent kinase inhibitor | SCHERING CORP (US) | 2009-10-14 | — | — | CN | claimed |
| CN-101300241-A | Piperazine derivatives as antimalarial agents | ACTELION PHARMACEUTICALS LTD (CH) | 2008-11-05 | — | — | CN | claimed |
| US-20080234272-A1 | Novel Piperazines as Antimalarial Agents | ACTELION PHARMACEUTICALS LTD. (CH) | 2008-09-25 | — | — | US | claimed |
| EP-1940814-A1 | PIPERAZINE DERIVATIVES AS ANTIMALARIAL AGENTS | Actelion Pharmaceuticals Ltd. (CH) | 2008-07-09 | — | — | EP | claimed |
| WO-2007046075-A1 | PIPERAZINE DERIVATIVES AS ANTIMALARIAL AGENTS | ACTELION PHARMACEUTICALS LTD (CH) | 2007-04-26 | — | — | WO | claimed |
| CN-1373662-A | 3(5)-amino-pyrazole derivs., process for their preparation and their use as antitumor agents | PHARMACIA & UP JOHN S P A (IT) | 2002-10-09 | — | — | CN | claimed |
| CN-1342157-A | Substituted pyrazoles ASP38 kinase inhibitors | SEARLE & CO (US) | 2002-03-27 | — | — | CN | claimed |
| CN-1310716-A | Tricyclic sulfonamides and their derivatives as inhibitors of matrix metalloproteinases | WARNER LAMBERT CO (US) | 2001-08-29 | — | — | CN | claimed |
| CN-1227548-A | Substituted p-trifluoromethylphenyluracils | BAYER AG (DE) | 1999-09-01 | — | — | CN | claimed |
| CN-1216538-A | Substituted 2-aryl-1,2,4-triazine-3,5-di(thi) ones as herbicides | BAYER AG (DE) | 1999-05-12 | — | — | CN | claimed |
| CN-1175249-A | 3-aryl-1, 2, 4-triazole derivatives having herbicidal properties | BAYER AG (DE) | 1998-03-04 | — | — | CN | claimed |
| EP-0544819-B1 | INDOLE DERIVATIVES WHICH INHIBIT LEUKOTRIENE BIOSYNTHESIS | ABBOTT LAB (US) | 1995-12-06 | — | — | EP | claimed |
| EP-0544819-A4 | INDOLE DERIVATIVES WHICH INHIBIT LEUKOTRIENE BIOSYNTHESIS | — | 1993-10-20 | — | — | EP | claimed |
| EP-0544819-A1 | INDOLE DERIVATIVES WHICH INHIBIT LEUKOTRIENE BIOSYNTHESIS. | ABBOTT LAB (US) | 1993-06-09 | — | — | EP | claimed |
| WO-1992003132-A1 | INDOLE DERIVATIVES WHICH INHIBIT LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1992-03-05 | — | — | WO | claimed |