Water

Water

SCHEMBL1276018

C=Cc1nccs1.O

nearest known ligand 0.00

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2403062 0.97 ALDH1A1 (0.42)
SCHEMBL39666 0.97
Bromide SCHEMBL4252005 0.95
Hydrochlorthiazide SCHEMBL5945473 0.82 ALDH1A1 (0.31)
SCHEMBL11037482 0.79 RAB9A (0.45)
SCHEMBL15870899 0.76 RIOK2 (0.49)
SCHEMBL29769344 0.75 ALDH1A1 (0.40)
SCHEMBL1255596 0.75 ALDH1A1 (0.40)
SCHEMBL29769345 0.75 ALDH1A1 (0.40)
Water SCHEMBL27898216 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110891981-B Radiation curable coating composition for improving surface properties of plastics 阿科玛法国公司 2022-03-29 CN disclosed
US-11174393-B2 Radiation-curable coating composition for improving the surface properties of plastics ARKEMA FRANCE (FR) 2021-11-16 US disclosed
US-20210130622-A1 A RADIATION-CURABLE COATING COMPOSITION FOR IMPROVING THE SURFACE PROPERTIES OF PLASTICS ARKEMA FRANCE (FR) 2021-05-06 US disclosed
EP-3428199-B1 A RADIATION-CURABLE COATING COMPOSITION FOR IMPROVING THE SURFACE PROPERTIES OF PLASTICS ARKEMA FRANCE (FR) 2020-08-19 EP disclosed
EP-3652220-A1 A RADIATION-CURABLE COATING COMPOSITION FOR IMPROVING THE SURFACE PROPERTIES OF PLASTICS Arkema France (FR) 2020-05-20 EP disclosed
WO-2019011784-A1 A RADIATION-CURABLE COATING COMPOSITION FOR IMPROVING THE SURFACE PROPERTIES OF PLASTICS ARKEMA FRANCE (FR) 2019-01-17 WO disclosed
EP-3428199-A1 A RADIATION-CURABLE COATING COMPOSITION FOR IMPROVING THE SURFACE PROPERTIES OF PLASTICS ARKEMA FRANCE (FR) 2019-01-16 EP disclosed
US-7879938-B2 surface-modified inorganic particles have groups which interact with polymer in a van der Waals bond, hydrogen bridge bond, an electrostatic bond, ionic bond and/or a coordinative bond and/or a covalent bond; impact strength, ductility, heat resistance; polycaprolactam EVONIK DEGUSSA GMBH (DE) 2011-02-01 US disclosed
US-20080242782-A1 Compositions comprising an organic polymer as the matrix and inorganic particles as the filler, process for the preparation thereof and applications of the same DEGUSSA GMBH (DE) 2008-10-02 US disclosed
US-20050084993-A1 Light-guiding bodies and method for the production thereof ROEHM GBMH & CO. KG (DE) 2005-04-21 US disclosed