Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.49 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3604137 | 1.00 | ADORA1 (0.56) | ADORA1PTGS2CHEK1CDK2AP1RAB9A | |
| SCHEMBL3598892 | 1.00 | ADORA1 (0.56) | ADORA1PTGS2CHEK1CDK2AP1RAB9A | |
| SCHEMBL3602954 | 0.93 | ADORA1 (0.53) | ADORA1PTGS2CHEK1CDK2AP1RAB9A | |
| SCHEMBL3609809 | 0.93 | ADORA1 (0.53) | ADORA1PTGS2CHEK1CDK2AP1RAB9A | |
| SCHEMBL3602952 | 0.93 | ADORA1 (0.53) | ADORA1PTGS2CHEK1CDK2AP1RAB9A | |
| SCHEMBL3610473 | 0.89 | PTGS2 (0.67) | ADORA1PTGS2CHEK1CDK2AP1RAB9A | |
| SCHEMBL3610471 | 0.89 | PTGS2 (0.67) | ADORA1PTGS2CHEK1CDK2AP1RAB9A | |
| SCHEMBL15506889 | 0.87 | ADORA1 (0.68) | ADORA1PTGS2RAB9AALDH1A1SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL3607518 | 0.86 | ADORA1 (0.47) | ADORA1PTGS2CHEK1CDK2AP1RAB9A | |
| Trifluoroacetic Acid SCHEMBL3613647 | 0.86 | ADORA1 (0.47) | ADORA1PTGS2CHEK1CDK2AP1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | claimed |
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | IDO2, IDO1, INMT | ADORA1 407/4885PTGS2 356/4885CHEK1 1121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.