Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.43 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5155836 | 0.88 | KDM4E (0.47) | KDM4EECE2SHMT2NPC1RAB9A | |
| SCHEMBL31287242 | 0.88 | KDM4E (0.47) | KDM4EECE2SHMT2NPC1RAB9A | |
| SCHEMBL4280865 | 0.81 | ECE2 (0.41) | KDM4EECE2SHMT2NPC1RAB9A | |
| SCHEMBL6763074 | 0.79 | ECE2 (0.49) | KDM4EECE2SHMT2NPC1RAB9A | |
| Bromide SCHEMBL4280985 | 0.79 | ECE2 (0.40) | KDM4EECE2SHMT2NPC1RAB9A | |
| SCHEMBL3809978 | 0.79 | ECE2 (0.40) | KDM4EECE2PDE3BPDE3AP2RY12 | |
| SCHEMBL6360170 | 0.79 | ALDH1A1 (0.51) | PDE3BPDE3AP2RY12RAB9AEPHX2 | |
| SCHEMBL3158800 | 0.79 | DAO (0.51) | KDM4EPDE3BPDE3AP2RY12NPC1 | |
| SCHEMBL6347222 | 0.78 | ESR1 (0.47) | KDM4ERAB9AALDH1A1GAAMAPT | |
| Hydrochloric Acid SCHEMBL9196645 | 0.78 | ECE2 (0.47) | KDM4EECE2SHMT2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450352-B2 | Thiazole compounds and their use for inhibiting phosphodiesterase 4, TNF-α, and IL-4 | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-05-28 | — | — | US | disclosed |
| US-7715455-B2 | Solar light pumped laser and cooling method of solar light pumped laser | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2010-05-11 | — | — | US | disclosed |
| US-20100094002-A1 | Thiazole Compound and Use Thereof | OTSUKA PHARMACEUTICAL CO., LTD. | 2010-04-15 | — | — | US | disclosed |
| WO-2009153536-A1 | 1-AZA-BICYCLO [2.2.2] OCTANE DERIVATIVES USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | ARGENTA DISCOVERY LIMITED (GB) | 2009-12-23 | — | — | WO | disclosed |
| WO-2009153536-A1 | 1-AZA-BICYCLO [2.2.2] OCTANE DERIVATIVES USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | ARGENTA DISCOVERY LIMITED (GB) | 2009-12-23 | — | — | WO | disclosed |
| US-20080225912-A1 | Solar Light Pumped Laser and Cooling Method of Solar Light Pumped Laser | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2008-09-18 | — | — | US | disclosed |
| EP-1860747-A1 | SOLAR LIGHT PUMPED LASER AND COOLING SYSTEM OF SOLAR LIGHT PUMPED LASER | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2007-11-28 | — | — | EP | disclosed |
| CN-1585775-A | 6-O-acyl ketolide derivatives of erythromycine useful as antibacterials | ORTHO MCNEIL PHARM INC (US) | 2005-02-23 | — | — | CN | disclosed |
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100094002-A1 | Thiazole Compound and Use Thereof | PDE3B, IL4, PDE4A | KDM4E 2320/4885ECE2 412/4885PDE3B 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.