Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.35 |
| ▸ | CDK2AP1 | O14519 | 2/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | MC5R | P33032 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3601876 | 0.89 | HDAC4 (0.37) | HTR6HDAC4HDAC6HTR2AKCNH2 | |
| SCHEMBL3612519 | 0.87 | MAPK1 (0.37) | HDAC4HDAC6HTR2AKCNH2DRD4 | |
| SCHEMBL3606656 | 0.86 | PARP1 (0.41) | HDAC4HDAC6MAPK1OPRK1PARP1 | |
| SCHEMBL3595472 | 0.86 | MAPK1 (0.37) | HDAC4HDAC6HTR2AKCNH2DRD4 | |
| SCHEMBL3612512 | 0.85 | HTR6 (0.38) | HTR6HDAC4HDAC6DRD4MAPK1 | |
| SCHEMBL3615739 | 0.83 | MAPK1 (0.36) | PTGS2HDAC4HDAC6DRD4MAPK1 | |
| SCHEMBL3612662 | 0.83 | ADORA1 (0.45) | PTGS2HDAC4MAPK1OPRK1JAK2 | |
| SCHEMBL3598969 | 0.81 | EPHX1 (0.41) | PTGS2HDAC4MAPK1OPRK1JAK2 | |
| SCHEMBL3595862 | 0.81 | CDK2 (0.42) | HTR6HDAC4DRD4SSTR1SSTR4 | |
| SCHEMBL3599370 | 0.78 | CDK2 (0.41) | HTR6HDAC4HDAC6HTR2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | IDO2, IDO1, INMT | HTR6 129/4885PTGS2 356/4885HDAC4 134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.