Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 13/20 | 0.50 |
| ▸ | ACE | P12821 | 3/20 | 0.44 |
| ▸ | F11 | P03951 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3609812 | 0.86 | XIAP (0.55) | XIAPACE | |
| SCHEMBL3602616 | 0.83 | XIAP (0.50) | XIAPACEF11KMT2A | |
| SCHEMBL3607633 | 0.83 | XIAP (0.53) | XIAPACEF11MEN1KMT2A | |
| SCHEMBL3604048 | 0.82 | XIAP (0.49) | XIAPACE | |
| SCHEMBL3610720 | 0.78 | XIAP (0.46) | XIAPACEMEN1KMT2ATDP1 | |
| SCHEMBL3612823 | 0.75 | XIAP (0.44) | XIAPACEF11 | |
| SCHEMBL3613659 | 0.75 | XIAP (0.44) | XIAPACE | |
| SCHEMBL8800082 | 0.74 | KMT2A (0.55) | MEN1KMT2ATDP1 | |
| SCHEMBL3606601 | 0.74 | XIAP (0.42) | XIAPACE | |
| Hydrochloric Acid SCHEMBL3611807 | 0.74 | XIAP (0.44) | XIAPACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100022582-A1 | Tetrahydroisoquinoline Compound and Medicinal Use Thereof | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2010-01-28 | — | — | US | disclosed |
| EP-1857444-A1 | TETRAHYDROISOQUINOLINE COMPOUND AND MEDICINAL USE THEREOF | Kyoto Pharmaceutical Industries, Ltd. (JP) | 2007-11-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022582-A1 | Tetrahydroisoquinoline Compound and Medicinal Use Thereof | ACAT1, ACAT2, LCAT | XIAP 934/4885ACE 166/4885F11 4805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.