Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.86 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.86 |
| ▸ | NT5E | P21589 | 1/20 | 0.86 |
| ▸ | CA2 | P00918 | 6/20 | 0.64 |
| ▸ | CA1 | P00915 | 5/20 | 0.64 |
| ▸ | CA12 | O43570 | 5/20 | 0.64 |
| ▸ | CA9 | Q16790 | 5/20 | 0.64 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | MPO | P05164 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | AGO2 | Q9UKV8 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | CA6 | P23280 | 1/20 | 0.52 |
| ▸ | CA5A | P35218 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL482994 | 0.93 | TSHR (1.00) | TSHRALDH1A1NT5ECA2CA1 | |
| SCHEMBL24407 | 0.93 | TSHR (1.00) | TSHRALDH1A1NT5ECA2CA1 | |
| SCHEMBL31415204 | 0.93 | TSHR (1.00) | TSHRALDH1A1NT5ECA2CA1 | |
| SCHEMBL30495973 | 0.93 | TSHR (1.00) | TSHRALDH1A1NT5ECA2CA1 | |
| Water SCHEMBL8586611 | 0.90 | TSHR (0.95) | TSHRALDH1A1NT5ECA2CA1 | |
| SCHEMBL7766917 | 0.90 | TSHR (0.95) | TSHRALDH1A1NT5ECA2CA1 | |
| Sulfuric Acid SCHEMBL8646805 | 0.90 | TSHR (0.95) | TSHRALDH1A1NT5ECA2CA1 | |
| Ammonia Solution, Strong SCHEMBL3841064 | 0.90 | TSHR (0.95) | TSHRALDH1A1NT5ECA2CA1 | |
| Fluoride SCHEMBL5859726 | 0.90 | TSHR (0.95) | TSHRALDH1A1NT5ECA2CA1 | |
| Sulfuric Acid SCHEMBL10596856 | 0.90 | TSHR (0.95) | TSHRALDH1A1NT5ECA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137298-A1 | Biaryl Sulfonamides and Methods for Using Same | WYETH (US) | 2010-06-03 | — | — | US | disclosed |
| US-20100137298-A1 | Biaryl Sulfonamides and Methods for Using Same | WYETH (US) | 2010-06-03 | — | — | US | disclosed |
| US-20100137298-A1 | Biaryl Sulfonamides and Methods for Using Same | WYETH (US) | 2010-06-03 | — | — | US | disclosed |
| EP-1692124-B1 | BIARYL SULFONAMIDES AS MMP INHIBITORS | WYETH CORP (US) | 2008-10-15 | — | — | EP | disclosed |
| US-7420001-B2 | Biaryl sulfonamides and methods for using same | WYETH (US) | 2008-09-02 | — | — | US | disclosed |
| US-7420001-B2 | Biaryl sulfonamides and methods for using same | WYETH (US) | 2008-09-02 | — | — | US | disclosed |
| US-7420001-B2 | Biaryl sulfonamides and methods for using same | WYETH (US) | 2008-09-02 | — | — | US | disclosed |
| EP-1692124-A1 | BIARYL SULFONAMIDES AS MMP INHIBITORS | Wyeth (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005061477-A1 | BIARYL SULFONAMIDES AS MMP INHIBITORS | WYETH (US) | 2005-07-07 | — | — | WO | disclosed |
| WO-2005061477-A1 | BIARYL SULFONAMIDES AS MMP INHIBITORS | WYETH (US) | 2005-07-07 | — | — | WO | disclosed |
| US-20050143422-A1 | Biaryl sulfonamides and methods for using same | WYETH (US) | 2005-06-30 | — | — | US | disclosed |
| EP-0688830-B1 | Azo compounds and polarizing films using the compounds | MITSUI CHEMICALS INC (JP) | 1998-11-18 | — | — | EP | disclosed |
| US-5698682-A | HIGH HEAT RESISTANCE; EXCELLENT OPTICAL PROPERTIES; DICHROIC DYES | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-12-16 | — | — | US | disclosed |
| US-5639809-A | AZO COMPOUND DISTRIBUTED IN POLYMER FILM; HEAT RESISTANCE | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0688830-A1 | Azo compounds and polarizing films using the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1995-12-27 | — | — | EP | disclosed |
| US-4042618-A | FIBER AND FILM FORMING POLYMERS | CELANESE CORPORATION (US) | 1977-08-16 | — | — | US | disclosed |
| US-4017478-A | Water-soluble azo dyes having a 2-acetoacetamidofluorenyl coupling component radical | SANDOZ LTD. (CH) | 1977-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137298-A1 | Biaryl Sulfonamides and Methods for Using Same | STS, MMP3, AADAC | TSHR 4078/4885ALDH1A1 634/4885NT5E 1037/4885 |
| US-20050143422-A1 | Biaryl sulfonamides and methods for using same | STS, MMP3, AADAC | TSHR 4078/4885ALDH1A1 634/4885NT5E 1037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.