Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 2/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KHK | P50053 | 3/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3609488 | 0.85 | KDM5A (0.39) | KDM5AKDM4CKDM5BKHK | |
| SCHEMBL3604982 | 0.72 | PTGS2 (0.41) | KDM5AKDM4CKDM5BKHKMAPK14 | |
| SCHEMBL3616251 | 0.71 | ALDH1A1 (0.35) | KDM5AKDM4CKDM5BALDH1A1LMNA | |
| SCHEMBL3607017 | 0.69 | PTGS2 (0.40) | KDM5AKDM4CKDM5BKHK | |
| SCHEMBL3607929 | 0.69 | PTGS2 (0.38) | KDM5AKDM4CKDM5BKHK | |
| SCHEMBL3601173 | 0.69 | PTGS2 (0.40) | KDM5AKDM4CKDM5BKHK | |
| SCHEMBL3602376 | 0.68 | PTGS2 (0.41) | KDM5AKDM4CKDM5BKHKMAPK14 | |
| SCHEMBL3609481 | 0.67 | PTGS2 (0.44) | KDM5AKDM4CKDM5BKHK | |
| SCHEMBL3598570 | 0.67 | KHK (0.43) | KDM5AKDM4CKDM5BFFAR4KHK | |
| SCHEMBL27721970 | 0.67 | KDM5A (0.45) | KDM5AKDM4CKDM5BKHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723348-B2 | Phosphodiesterase 4 inhibitors | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-05-25 | — | — | US | disclosed |
| US-20080207660-A1 | PHOSPHODIESTERASE 4 INHIBITORS | HOPPER ALLEN | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207660-A1 | PHOSPHODIESTERASE 4 INHIBITORS | PDE4A, PDE4B, PDE12 | KDM5A 622/4885KDM4C 294/4885KDM5B 592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.