Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 7/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.62 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.33 |
| ▸ | ICMT | O60725 | 1/20 | 0.30 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3615567 | 0.79 | KCNA5 (0.64) | KCNA5KCNH2GRIA2GRIA4CSNK1E | |
| SCHEMBL3623830 | 0.77 | KCNA5 (1.00) | KCNA5KCNH2GRIA2GRIA4 | |
| SCHEMBL3624316 | 0.77 | KCNA5 (0.77) | KCNA5KCNH2GRIA2GRIA4 | |
| SCHEMBL3624917 | 0.76 | KCNA5 (0.46) | KCNA5KCNH2ICMT | |
| SCHEMBL3620685 | 0.76 | KCNA5 (0.46) | KCNA5KCNH2GRIA2GRIA4 | |
| SCHEMBL3623938 | 0.75 | KCNA5 (0.69) | KCNA5KCNH2GRIA2GRIA4ICMT | |
| SCHEMBL3621897 | 0.75 | KCNA5 (0.69) | KCNA5KCNH2GRIA2GRIA4ICMT | |
| SCHEMBL3621579 | 0.75 | KCNA5 (0.66) | KCNA5KCNH2GRIA2GRIA4 | |
| SCHEMBL1384242 | 0.73 | KCNA5 (0.65) | KCNA5KCNH2GRIA2GRIA4 | |
| SCHEMBL3623280 | 0.71 | KCNA5 (1.00) | KCNA5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7763614-B2 | Isoquinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-07-27 | — | — | US | claimed |
| US-7763614-B2 | Isoquinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-07-27 | — | — | US | disclosed |
| US-20070054892-A1 | Isoquinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054892-A1 | Isoquinoline potassium channel inhibitors | KCNQ1, KCNQ2, KCNQ5 | KCNA5 14/4885KCNH2 5/4885GRIA2 1167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.