Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 7/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.69 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | TPI1 | P60174 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | ICMT | O60725 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3624316 | 0.85 | KCNA5 (0.77) | KCNA5KCNH2GRIA2GRIA4DPP4 | |
| SCHEMBL3623938 | 0.84 | KCNA5 (0.69) | KCNA5KCNH2GRIA2GRIA4RIPK3 | |
| SCHEMBL3623830 | 0.81 | KCNA5 (1.00) | KCNA5KCNH2GRIA2GRIA4DPP4 | |
| SCHEMBL3621579 | 0.81 | KCNA5 (0.66) | KCNA5KCNH2GRIA2GRIA4DPP4 | |
| SCHEMBL1384242 | 0.80 | KCNA5 (0.65) | KCNA5KCNH2GRIA2GRIA4DPP4 | |
| Trifluoroacetic Acid SCHEMBL3615567 | 0.78 | KCNA5 (0.64) | KCNA5KCNH2GRIA2GRIA4DPP4 | |
| SCHEMBL3615570 | 0.75 | KCNA5 (0.62) | KCNA5KCNH2GRIA2GRIA4ICMT | |
| SCHEMBL3624115 | 0.72 | KCNA5 (0.43) | KCNA5KCNH2DPP4HSP90AB1 | |
| SCHEMBL1385042 | 0.72 | KCNA5 (0.82) | KCNA5KCNH2DPP4 | |
| SCHEMBL3623280 | 0.72 | KCNA5 (1.00) | KCNA5KCNH2DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7763614-B2 | Isoquinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-07-27 | — | — | US | claimed |
| US-20070054892-A1 | Isoquinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. | 2007-03-08 | — | — | US | claimed |
| US-7763614-B2 | Isoquinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-07-27 | — | — | US | disclosed |
| US-20070054892-A1 | Isoquinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054892-A1 | Isoquinoline potassium channel inhibitors | KCNQ1, KCNQ2, KCNQ5 | KCNA5 14/4885KCNH2 5/4885GRIA2 1167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.