Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 7/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.77 |
| ▸ | DPP4 | P27487 | 4/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | WEE1 | P30291 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESRRA | P11474 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3623830 | 0.87 | KCNA5 (1.00) | KCNA5KCNH2DPP4GRIA2GRIA4 | |
| SCHEMBL3623938 | 0.85 | KCNA5 (0.69) | KCNA5KCNH2DPP4CHEK1GRIA2 | |
| SCHEMBL3621897 | 0.85 | KCNA5 (0.69) | KCNA5KCNH2DPP4CHEK1GRIA2 | |
| SCHEMBL3621579 | 0.82 | KCNA5 (0.66) | KCNA5KCNH2DPP4GRIA2GRIA4 | |
| SCHEMBL3111741 | 0.82 | KCNA5 (0.56) | KCNA5KCNH2DPP4CHEK1WEE1 | |
| SCHEMBL1384242 | 0.82 | KCNA5 (0.65) | KCNA5KCNH2DPP4GRIA2GRIA4 | |
| Trifluoroacetic Acid SCHEMBL3615567 | 0.79 | KCNA5 (0.64) | KCNA5KCNH2DPP4GRIA2GRIA4 | |
| SCHEMBL1385042 | 0.77 | KCNA5 (0.82) | KCNA5KCNH2DPP4 | |
| SCHEMBL3615570 | 0.77 | KCNA5 (0.62) | KCNA5KCNH2GRIA2GRIA4 | |
| SCHEMBL13283562 | 0.76 | KCNA5 (0.82) | KCNA5KCNH2DPP4GRIA2GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7763614-B2 | Isoquinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-07-27 | — | — | US | disclosed |
| US-20070054892-A1 | Isoquinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054892-A1 | Isoquinoline potassium channel inhibitors | KCNQ1, KCNQ2, KCNQ5 | KCNA5 14/4885KCNH2 5/4885DPP4 2227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.