Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | PRKCG | P05129 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | FES | P07332 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
| ▸ | FER | P16591 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3613483 | 0.91 | PARP1 (0.42) | ALDH1A1CHEK1ROCK1ROCK2LMNA | |
| SCHEMBL3622686 | 0.89 | RAB9A (0.47) | ALDH1A1POLBJAK2LMNAHTT | |
| SCHEMBL14373980 | 0.86 | CHEK1 (0.40) | ADORA1ALDH1A1CHEK1JAK2RET | |
| SCHEMBL3622445 | 0.84 | ALDH1A1 (0.41) | ADORA2AADORA1ALDH1A1CHEK1JAK2 | |
| SCHEMBL3619318 | 0.84 | CHEK1 (0.51) | ADORA2AADORA1ALDH1A1CHEK1JAK2 | |
| SCHEMBL4458883 | 0.83 | RAB9A (0.42) | ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3625972 | 0.82 | JAK2 (0.38) | ADORA3ADORA2AADORA1CHEK1JAK2 | |
| SCHEMBL3618943 | 0.78 | HPGD (0.43) | ALDH1A1CHEK1JAK2RETFLT1 | |
| SCHEMBL3620214 | 0.78 | HTR2B (0.40) | ALDH1A1CHEK1JAK2RETFLT1 | |
| SCHEMBL3618920 | 0.76 | JAK2 (0.42) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032141-B1 | INHIBITORS OF JANUS KINASES | MERCK SHARP & DOHME (US) | 2012-10-31 | — | — | EP | claimed |
| US-20090306071-A1 | Inhibitors of Janus Kinases | MERCK SHARP & DOHME LLC | 2009-12-10 | — | — | US | claimed |
| EP-2032141-B1 | INHIBITORS OF JANUS KINASES | MERCK SHARP & DOHME (US) | 2012-10-31 | — | — | EP | disclosed |
| US-7763634-B2 | Inhibitors of janus kinases | MERCK & CO., INC. (US) | 2010-07-27 | — | — | US | disclosed |
| US-20090306071-A1 | Inhibitors of Janus Kinases | MERCK SHARP & DOHME LLC | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306071-A1 | Inhibitors of Janus Kinases | JAK2, JAK3, JAK1 | IMPDH2 2494/4885ADORA3 3115/4885ADORA2A 4253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.