Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.56 |
| ▸ | HPGD | P15428 | 6/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 7/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | GLA | P06280 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8930739 | 0.83 | ALDH1A1 (0.40) | KDM4EHPGDTSHRHSD17B10GAA | |
| SCHEMBL8930736 | 0.82 | KDM4E (0.45) | KDM4EHPGDTSHRHSD17B10GAA | |
| SCHEMBL7399942 | 0.81 | ALDH1A1 (0.39) | KDM4EHPGDTSHRHSD17B10GAA | |
| SCHEMBL4784858 | 0.80 | ALDH1A1 (0.44) | KDM4EHPGDGAAL3MBTL1ALDH1A1 | |
| SCHEMBL3626955 | 0.79 | KDM4E (0.53) | KDM4EHPGDTSHRHSD17B10GAA | |
| SCHEMBL9408906 | 0.79 | KDM4E (0.53) | KDM4EHPGDTSHRHSD17B10GAA | |
| SCHEMBL10671006 | 0.79 | KDM4E (0.53) | KDM4EHPGDTSHRHSD17B10GAA | |
| SCHEMBL9408904 | 0.79 | KDM4E (0.53) | KDM4EHPGDTSHRHSD17B10GAA | |
| SCHEMBL29072360 | 0.77 | KDM4E (0.56) | KDM4EHPGDTSHRHSD17B10GAA | |
| SCHEMBL29072362 | 0.77 | KDM4E (0.56) | KDM4EHPGDTSHRHSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578729-A4 | 1-ALKYL-3-AMINOINDAZOLES | ALCON INC (CH) | 2007-08-29 | — | — | EP | claimed |
| US-20060052613-A1 | 1-alkyl-3-aminoindazoles | ALCON, INC. (CH) | 2006-03-09 | — | — | US | claimed |
| EP-1578729-A1 | 1-ALKYL-3-AMINOINDAZOLES | Alcon, Inc. (CH) | 2005-09-28 | — | — | EP | claimed |
| WO-2004058725-A1 | 1-ALKYL-3-AMINOINDAZOLES | ALCON, INC. (CH) | 2004-07-15 | — | — | WO | claimed |
| US-6433116-B1 | — | — | None | — | — | US | disclosed |
| US-7799930-B2 | 1-alkyl-3-aminoindazoles | ALCON, INC. (CH) | 2010-09-21 | — | — | US | disclosed |
| US-7799930-B2 | 1-alkyl-3-aminoindazoles | ALCON, INC. (CH) | 2010-09-21 | — | — | US | disclosed |
| US-20090149659-A1 | 1-ALKYL-3-AMINOINDAZOLES | ALCON, INC. (CH) | 2009-06-11 | — | — | US | disclosed |
| US-20090149659-A1 | 1-ALKYL-3-AMINOINDAZOLES | ALCON, INC. (CH) | 2009-06-11 | — | — | US | disclosed |
| CN-100361977-C | 1-alkyl-3-aminoindazoles | ALCON INC (CH) | 2008-01-16 | — | — | CN | disclosed |
| EP-1578729-A4 | 1-ALKYL-3-AMINOINDAZOLES | ALCON INC (CH) | 2007-08-29 | — | — | EP | disclosed |
| EP-1578729-A4 | 1-ALKYL-3-AMINOINDAZOLES | ALCON INC (CH) | 2007-08-29 | — | — | EP | disclosed |
| US-20010018516-A1 | Oxazoline or oxazine acetoacetate aqueous coating compositions | BASF CORPORATION | 2001-08-30 | — | — | US | disclosed |
| US-6235901-B1 | CAN BE POLYMERIZED AND/OR COPOLYMERIZED BY CATONIC POLYMERIZATION; CAN BE CROSSLINKED AND ARE USEFUL IN COATINGS, INKS, OVERPRINT VARNISHES, AND SURFACE TREATMENT APPLICATIONS. | S. C. JOHNSON COMMERCIAL MARKETS, INC. | 2001-05-22 | — | — | US | disclosed |
| WO-2000068212-A1 | OXAZOLINE OR OXAZINE ACETOACETATE AQUEOUS COATING COMPOSITIONS | S. C. JOHNSON COMMERCIAL MARKETS, INC. (US) | 2000-11-16 | — | — | WO | disclosed |
| US-5929072-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY LIMITED (GB) | 1999-07-27 | — | — | US | disclosed |
| WO-1999010346-A1 | BENZOTHIADIAZINYL-INDOLE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR LIGANDS | ELI LILLY AND COMPANY LIMITED (GB) | 1999-03-04 | — | — | WO | disclosed |
| EP-0897921-A1 | Benzothiadiazinyl-indole derivatives and their use as serotonin receptor ligands | ELI LILLY AND COMPANY LIMITED (GB) | 1999-02-24 | — | — | EP | disclosed |
| US-5612353-A | ANTICOAGULANT | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-03-18 | — | — | US | disclosed |
| US-4211783-A | Hypolipidemic and antiatherosclerotic novel 4-(aralkyl- and heteroarylalkylamino)phenyl compounds | AMERICAN CYANAMID COMPANY (US) | 1980-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052613-A1 | 1-alkyl-3-aminoindazoles | NAT1, AADAC, CYP1B1 | KDM4E 2238/4885HPGD 136/4885TSHR 4021/4885 |
| US-20010018516-A1 | Oxazoline or oxazine acetoacetate aqueous coating compositions | ITGB7, DNMT3A, KAT7 | KDM4E 567/4885HPGD 3068/4885TSHR 2758/4885 |
| US-20090149659-A1 | 1-ALKYL-3-AMINOINDAZOLES | NAT1, AADAC, CYP1B1 | KDM4E 2238/4885HPGD 136/4885TSHR 4021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.