Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.72 |
| ▸ | RAB9A | P51151 | 7/20 | 0.59 |
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.53 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.53 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.53 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2198563 | 0.84 | PIM1 (1.00) | PIM1RAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL29523120 | 0.84 | PIM1 (1.00) | PIM1RAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL2705460 | 0.84 | PIM1 (0.74) | PIM1RAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL1297716 | 0.82 | PIM1 (0.72) | PIM1RAB9ANPC1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL10423094 | 0.82 | PIM1 (0.96) | PIM1RAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL18356154 | 0.81 | PIM1 (0.66) | PIM1RAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL6240008 | 0.81 | PIM1 (0.70) | PIM1RAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL9989803 | 0.80 | FLT3 (0.73) | PIM1ALDH1A1LMNASMN1; SMN2MAOA | |
| SCHEMBL3613922 | 0.80 | MAOB (0.63) | RAB9ANPC1ALDH1A1SMN1; SMN2GPR35 | |
| SCHEMBL3721823 | 0.79 | PIM1 (0.68) | PIM1RAB9ANPC1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021195603-A1 | ANTI-MALARIAL COMPOUNDS AND USES THEREOF | VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY (US) | 2021-09-30 | — | — | WO | disclosed |
| WO-2021195603-A1 | ANTI-MALARIAL COMPOUNDS AND USES THEREOF | VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY (US) | 2021-09-30 | — | — | WO | disclosed |
| WO-2020198435-A1 | SMALL MOLECULE DEGRADERS OF STAT3 | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-10-01 | — | — | WO | disclosed |
| US-20100137298-A1 | Biaryl Sulfonamides and Methods for Using Same | WYETH (US) | 2010-06-03 | — | — | US | disclosed |
| US-20090318479-A1 | SUBSTITUTED RING FUSED AZINES AND THEIR USE IN CANCER THERAPY | AUCKLAND UNISERVICES LIMITED | 2009-12-24 | — | — | US | disclosed |
| EP-1692124-B1 | BIARYL SULFONAMIDES AS MMP INHIBITORS | WYETH CORP (US) | 2008-10-15 | — | — | EP | disclosed |
| US-7420001-B2 | Biaryl sulfonamides and methods for using same | WYETH (US) | 2008-09-02 | — | — | US | disclosed |
| EP-1692124-A1 | BIARYL SULFONAMIDES AS MMP INHIBITORS | Wyeth (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005061477-A1 | BIARYL SULFONAMIDES AS MMP INHIBITORS | WYETH (US) | 2005-07-07 | — | — | WO | disclosed |
| US-20050143422-A1 | Biaryl sulfonamides and methods for using same | WYETH (US) | 2005-06-30 | — | — | US | disclosed |
| EP-1194426-B1 | BENZOFURANE DERIVATIVES | MERCK PATENT GMBH (DE) | 2004-08-18 | — | — | EP | disclosed |
| US-6531503-B1 | Central nervous system | MERCK PATENT GMBH (DE) | 2003-03-11 | — | — | US | disclosed |
| EP-1194426-A2 | BENZOFURANE DERIVATIVES | MERCK PATENT GmbH (DE) | 2002-04-10 | — | — | EP | disclosed |
| WO-2001004112-A2 | BENZOFURANE DERIVATIVES | MERCK PATENT GMBH (DE) | 2001-01-18 | — | — | WO | disclosed |
| EP-0147044-B1 | BENZOFURANCARBOXAMIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | ADRIA LABORATORIES INC. (US) | 1990-04-25 | — | — | EP | disclosed |
| EP-0147044-A2 | Benzofurancarboxamides, process for their preparation and pharmaceutical preparations containing them | ADRIA LABORATORIES INC. (US) | 1985-07-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137298-A1 | Biaryl Sulfonamides and Methods for Using Same | STS, MMP3, AADAC | PIM1 3322/4885RAB9A 3864/4885NPC1 2605/4885 |
| US-20050143422-A1 | Biaryl sulfonamides and methods for using same | STS, MMP3, AADAC | PIM1 3322/4885RAB9A 3864/4885NPC1 2605/4885 |
| US-20090318479-A1 | SUBSTITUTED RING FUSED AZINES AND THEIR USE IN CANCER THERAPY | TP53, AZI2, MCL1 | PIM1 1252/4885RAB9A 1026/4885NPC1 1687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.