Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.41 |
| ▸ | RBBP9 | O75884 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12181482 | 0.93 | MEN1 (0.54) | TNKSMEN1TSHRKMT2AALDH1A1 | |
| SCHEMBL5738394 | 0.92 | TSHR (0.60) | TNKSMEN1TSHRKMT2AALDH1A1 | |
| SCHEMBL29529436 | 0.89 | TNKS (0.47) | TNKSMEN1TSHRKMT2AALDH1A1 | |
| SCHEMBL5774113 | 0.89 | TNKS (0.45) | TNKSMEN1TSHRKMT2AALDH1A1 | |
| SCHEMBL29528962 | 0.88 | TNKS (0.44) | TNKSMEN1TSHRKMT2AALDH1A1 | |
| SCHEMBL29529071 | 0.85 | ALDH1A1 (0.44) | TNKSMEN1TSHRKMT2AALDH1A1 | |
| SCHEMBL29528959 | 0.85 | ALDH1A1 (0.44) | TNKSMEN1TSHRKMT2AALDH1A1 | |
| SCHEMBL3874026 | 0.83 | HRH3 (0.48) | TNKSALDH1A1HPGDCYP3A4CYP2D6 | |
| SCHEMBL16333688 | 0.81 | PBK (0.51) | — | |
| SCHEMBL16333685 | 0.81 | PBK (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100286181-A1 | PYRROLE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY | ASTRAZENECA AB (SE) | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286181-A1 | PYRROLE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY | PGLS, UROD, GMPS | TNKS 1217/4885MEN1 3485/4885TSHR 4453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.