Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19282358 | 0.97 | ALDH1A1 (0.52) | ALDH1A1TDP1CYP3A4TSHRCA2 | |
| SCHEMBL15462 | 0.95 | ALDH1A1 (0.54) | ALDH1A1TDP1CYP3A4TSHRCA2 | |
| SCHEMBL1449865 | 0.95 | ALDH1A1 (0.54) | ALDH1A1TDP1CYP3A4TSHRCA2 | |
| Zinc Ion SCHEMBL768293 | 0.95 | ALDH1A1 (0.54) | ALDH1A1TDP1CYP3A4TSHRCA2 | |
| SCHEMBL673226 | 0.95 | ALDH1A1 (0.54) | ALDH1A1TDP1CYP3A4TSHRCA2 | |
| SCHEMBL1025105 | 0.95 | ALDH1A1 (0.54) | ALDH1A1TDP1CYP3A4TSHRCA2 | |
| SCHEMBL9417629 | 0.95 | ALDH1A1 (0.54) | ALDH1A1TDP1CYP3A4TSHRCA2 | |
| Lithium Ion SCHEMBL1461667 | 0.95 | ALDH1A1 (0.54) | ALDH1A1TDP1CYP3A4TSHRCA2 | |
| Potassium Ion SCHEMBL3291106 | 0.95 | ALDH1A1 (0.54) | ALDH1A1TDP1CYP3A4TSHRCA2 | |
| SCHEMBL9417628 | 0.95 | ALDH1A1 (0.54) | ALDH1A1TDP1CYP3A4TSHRCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 270 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673166-A4 | ZIEGLER-NATTA CATALYST FOR POLYOLEFINS | FINA TECHNOLOGY (US) | 2009-06-17 | — | — | EP | claimed |
| EP-1306394-B1 | Ziegler-Natta catalyst for narrow to broad MWD of polyolefins, method of making, method of using, and polyolefins made therewith | TOTAL PETROCHEMICALS RES FELUY (BE) | 2008-06-04 | — | — | EP | claimed |
| EP-1306391-B1 | Ziegler-Natta catalyst for tuning MWD of polyolefin, method of making, method of using and polyolefins made therewith | TOTAL PETROCHEMICALS RES FELUY (BE) | 2008-04-30 | — | — | EP | claimed |
| JP-2007505970-A | — | — | 2007-03-15 | — | — | JP | claimed |
| EP-1673166-A1 | ZIEGLER-NATTA CATALYST FOR POLYOLEFINS | FINA TECHNOLOGY, INC. (US) | 2006-06-28 | — | — | EP | claimed |
| US-6916895-B2 | Ziegler-Natta catalyst for tuning MWD of polyolefin, method of making, method of using, and polyolefins made therewith | FINA TECHNOLOGY, INC. (US) | 2005-07-12 | — | — | US | claimed |
| WO-2005032714-A1 | ZIEGLER-NATTA CATALYST FOR POLYOLEFINS | FINA TECHNOLOGY, INC. (US) | 2005-04-14 | — | — | WO | claimed |
| US-6864207-B2 | Ziegler-Natta catalyst for polyolefins | FINA TECHNOLOGY, INC. (US) | 2005-03-08 | — | — | US | claimed |
| US-6734134-B1 | TREATING A MAGNESIUM DIALKOXIDE WITH TWO HALOGENATING/TITANATING AGENTS, THE SECOND STRONGER THAN THE FIRST, THEN AN ORGANOALUMINUM PREACTIVATING AGENT, HEAT TREATING | FINA TECHNOLOGY, INC. | 2004-05-11 | — | — | US | claimed |
| US-20040082740-A1 | Ziegler-natta catalyst for tuning MWD of polyolefin, method of making, method of using, and polyolefins made therewith | FINA TECHNOLOGY, INC. | 2004-04-29 | — | — | US | claimed |
| CN-1418893-A | Polyolefine catalyst, its making method, using method, and polymer made from said catalyst | FINA TECHNOLOGY (US) | 2003-05-21 | — | — | CN | claimed |
| EP-1308465-A1 | Improved hydrogen response Ziegler-Natta catalyst for narrowing MWD of polyolefin, method of making it, polymerisation process using it, and polyolefins made therewith | FINA TECHNOLOGY, INC. (US) | 2003-05-07 | — | — | EP | claimed |
| EP-1306391-A1 | Ziegler-Natta catalyst for tuning MWD of polyolefin, method of making, method of using and polyolefins made therewith | FINA TECHNOLOGY, INC. (US) | 2003-05-02 | — | — | EP | claimed |
| EP-1306394-A1 | Ziegler-Natta catalyst for narrow to broad MWD of polyolefins, method of making, method of using, and polyolefins made therewith | FINA TECHNOLOGY, INC. (US) | 2003-05-02 | — | — | EP | claimed |
| US-20030018143-A1 | Hydrogen response Ziegler-Natta catalyst for narrowing MWD of polyolefin, method of making, method of using, and polyolefins made therewith | GRAY STEVEN D (US) | 2003-01-23 | — | — | US | claimed |
| US-6486274-B1 | Hydrogen response Ziegler-Natta catalyst for narrowing MWD of polyolefin, method of making, method of using, and polyolefins made therewith | FINA TECHNOLOGY, INC. | 2002-11-26 | — | — | US | claimed |
| US-6174971-B1 | POLYMERIZATION CATALYSTS OF ALUMINUM AND MAGNESIUM COMPOUNDS | FINA TECHNOLOGY, INC. | 2001-01-16 | — | — | US | claimed |
| EP-0855409-A1 | Improved Ziegler-Natta catalysts for olefin polymerization | FINA TECHNOLOGY, INC. (US) | 1998-07-29 | — | — | EP | claimed |
| EP-0319173-B1 | Ziegler-Natta catalyst and a process for its preparation | BP CHEM INT LTD (GB) | 1994-01-05 | — | — | EP | claimed |
| US-4950631-A | PROPYLENE POLYMERIZATION CATALYST | QUANTUM CHEMICAL CORPORATION (US) | 1990-08-21 | — | — | US | claimed |